Adaptive behavior in adolescents and adults with Down syndrome: Results from a 6-month longitudinal study.

Journal Article (Journal Article;Multicenter Study)

Measures of adaptive behavior are important in the assessment and treatment of individuals with intellectual disabilities (ID). The purpose of the current study was to evaluate the stability of an established and a novel measure of adaptive behavior over time, and their suitability as outcome measures in clinical trials targeting individuals with Down syndrome (DS). This 6-month, longitudinal, noninterventional, multinational study included adolescents (12-17 years) and adults (18-30 years) with DS. Participants were from seven countries (11 different sites) with English, Spanish and French as their native language. The Vineland Adaptive Behavior Scales-II (VABS-II) and a newly developed Clinician Global Impression (CGI) scale were administered at baseline, 1 and 6 months. Adults had lower composite standard scores on all domains of the VABS-II compared with adolescents. The communication domain was a weakness relative to the socialization and daily living skills domains on the VABS-II and the CGI-Severity scale. These findings were stable over 6 months, as exhibited by high intraclass correlations (>0.75). These results provide valuable baseline data for use in trial design and endpoint selection for studies including individuals with DS. identifier: NCT01580384.

Full Text

Duke Authors

Cited Authors

  • Spiridigliozzi, GA; Goeldner, C; Edgin, J; Hart, SJ; Noeldeke, J; Squassante, L; Visootsak, J; Heller, JH; Khwaja, O; Kishnani, PS; Liogier d'Ardhuy, X

Published Date

  • January 2019

Published In

Volume / Issue

  • 179 / 1

Start / End Page

  • 85 - 93

PubMed ID

  • 30569586

Electronic International Standard Serial Number (EISSN)

  • 1552-4833

Digital Object Identifier (DOI)

  • 10.1002/ajmg.a.60685


  • eng

Conference Location

  • United States