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Potential retinal biomarkers for dementia: what is new?

Publication ,  Journal Article
Cheung, CY; Chan, VTT; Mok, VC; Chen, C; Wong, TY
Published in: Curr Opin Neurol
February 2019

PURPOSE OF REVIEW: To summarize the current findings on clinical retinal diseases and retinal imaging changes with dementia, focusing on Alzheimer's disease. RECENT FINDINGS: Studies observed that clinical retinal diseases such as age-related macular degeneration, open-angle glaucoma and diabetic retinopathy are related to dementia, but the associations are not entirely consistent. In terms of the retinal neuronal structure, multiple retinal neuronal layers are significantly thinner in Alzheimer's disease dementia, such as the parapapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GC-IPL). Recent studies further demonstrated that macular GC-IPL and macular RNFL are also significantly thinner in the preclinical stage of Alzheimer's disease. A thinner RNFL is also associated with a significantly increased risk of developing both cognitive decline and Alzheimer's disease dementia. In addition, studies consistently showed that retinal vascular changes are associated with poorer cognitive performance, as well as prevalent and incident Alzheimer's disease dementia. SUMMARY: The current findings support the concept that changes in the retina, particular in retinal neuronal structure and vasculature, can reflect the status of cerebral neuronal structure and vasculature, highlighting the potential role of retinal changes as biomarkers of dementia.

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Published In

Curr Opin Neurol

DOI

EISSN

1473-6551

Publication Date

February 2019

Volume

32

Issue

1

Start / End Page

82 / 91

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Neurons
  • Retinal Ganglion Cells
  • Retina
  • Neurology & Neurosurgery
  • Humans
  • Dementia
  • Biomarkers
  • 3209 Neurosciences
  • 3202 Clinical sciences
 

Citation

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Cheung, C. Y., Chan, V. T. T., Mok, V. C., Chen, C., & Wong, T. Y. (2019). Potential retinal biomarkers for dementia: what is new? Curr Opin Neurol, 32(1), 82–91. https://doi.org/10.1097/WCO.0000000000000645
Cheung, Carol Y., Victor T. T. Chan, Vincent C. Mok, Christopher Chen, and Tien Y. Wong. “Potential retinal biomarkers for dementia: what is new?Curr Opin Neurol 32, no. 1 (February 2019): 82–91. https://doi.org/10.1097/WCO.0000000000000645.
Cheung CY, Chan VTT, Mok VC, Chen C, Wong TY. Potential retinal biomarkers for dementia: what is new? Curr Opin Neurol. 2019 Feb;32(1):82–91.
Cheung, Carol Y., et al. “Potential retinal biomarkers for dementia: what is new?Curr Opin Neurol, vol. 32, no. 1, Feb. 2019, pp. 82–91. Pubmed, doi:10.1097/WCO.0000000000000645.
Cheung CY, Chan VTT, Mok VC, Chen C, Wong TY. Potential retinal biomarkers for dementia: what is new? Curr Opin Neurol. 2019 Feb;32(1):82–91.

Published In

Curr Opin Neurol

DOI

EISSN

1473-6551

Publication Date

February 2019

Volume

32

Issue

1

Start / End Page

82 / 91

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Neurons
  • Retinal Ganglion Cells
  • Retina
  • Neurology & Neurosurgery
  • Humans
  • Dementia
  • Biomarkers
  • 3209 Neurosciences
  • 3202 Clinical sciences