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Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain.

Publication ,  Journal Article
Chen, G; Zhang, Y-Q; Qadri, YJ; Serhan, CN; Ji, R-R
Published in: Neuron
December 19, 2018

The previous decade has seen a rapid increase in microglial studies on pain, with a unique focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous signaling molecules are altered in microglia and contribute to the pathogenesis of pain. Here, we discuss how microglial signaling regulates spinal cord synaptic plasticity in acute and chronic pain conditions with different degrees and variations of microgliosis. We highlight that microglial mediators such as pro- and anti-inflammatory cytokines are powerful neuromodulators that regulate synaptic transmission and pain via neuron-glial interactions. We also reveal an emerging role of microglia in the resolution of pain, in part via specialized pro-resolving mediators including resolvins, protectins, and maresins. We also discuss a possible role of microglia in chronic itch.

Duke Scholars

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Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

December 19, 2018

Volume

100

Issue

6

Start / End Page

1292 / 1311

Location

United States

Related Subject Headings

  • Up-Regulation
  • Signal Transduction
  • Pain Management
  • Pain
  • Neurology & Neurosurgery
  • Microglia
  • Inflammation
  • Humans
  • Cytokines
  • Central Nervous System
 

Citation

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Chen, G., Zhang, Y.-Q., Qadri, Y. J., Serhan, C. N., & Ji, R.-R. (2018). Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain. Neuron, 100(6), 1292–1311. https://doi.org/10.1016/j.neuron.2018.11.009
Chen, Gang, Yu-Qiu Zhang, Yawar J. Qadri, Charles N. Serhan, and Ru-Rong Ji. “Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain.Neuron 100, no. 6 (December 19, 2018): 1292–1311. https://doi.org/10.1016/j.neuron.2018.11.009.
Chen G, Zhang Y-Q, Qadri YJ, Serhan CN, Ji R-R. Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain. Neuron. 2018 Dec 19;100(6):1292–311.
Chen, Gang, et al. “Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain.Neuron, vol. 100, no. 6, Dec. 2018, pp. 1292–311. Pubmed, doi:10.1016/j.neuron.2018.11.009.
Chen G, Zhang Y-Q, Qadri YJ, Serhan CN, Ji R-R. Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain. Neuron. 2018 Dec 19;100(6):1292–1311.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

December 19, 2018

Volume

100

Issue

6

Start / End Page

1292 / 1311

Location

United States

Related Subject Headings

  • Up-Regulation
  • Signal Transduction
  • Pain Management
  • Pain
  • Neurology & Neurosurgery
  • Microglia
  • Inflammation
  • Humans
  • Cytokines
  • Central Nervous System