Emerging immunotherapies for autoimmune kidney disease.
Journal Article (Review)
Autoimmunity is a leading cause of chronic kidney disease and loss of native and transplanted kidneys. Conventional immunosuppressive therapies can be effective but are non-specific, noncurative, and risk serious side effects such as life-threatening infection and cancer. Novel therapies and targeted interventions are urgently needed. In this brief review we explore diverse strategies currently in development and under consideration to interrupt underlying disease mechanisms in immune-mediated renal injury. Because autoantibodies are prominent in diagnosis and pathogenesis in multiple human glomerulopathies, we highlight several promising therapies that interfere with functions of early mediators (IgG and complement) of the effector arm and with an epicenter (the germinal center) for induction of humoral immunity.
Full Text
Duke Authors
Cited Authors
- Foster, MH; Ord, JR
Published Date
- 2019
Published In
Volume / Issue
- 15 / 4
Start / End Page
- 876 - 890
PubMed ID
- 30550361
Pubmed Central ID
- 30550361
Electronic International Standard Serial Number (EISSN)
- 2164-554X
Digital Object Identifier (DOI)
- 10.1080/21645515.2018.1555569
Language
- eng
Conference Location
- United States