Effects of Space Flight on Mouse Liver versus Kidney: Gene Pathway Analyses.

Journal Article (Journal Article)

Understanding genome wide, tissue-specific, and spaceflight-induced changes in gene expression is critical to develop effective countermeasures. Transcriptome analysis has been performed on diverse tissues harvested from animals flown in space, but not the kidney. We determined the genome wide gene expression using a gene array analysis of kidney and liver tissue from mice flown in space for 12 days versus ground based control animals. By comparing the transcriptome of liver and kidney from animals flown in space versus ground control animals, we tested a unique hypothesis: Are there common gene expression pathways activated in multiple tissue types in response to spaceflight stimuli? Although there were tissue-specific changes, both liver and kidney overexpressed genes in the same four areas: (a) cellular responses to peptides, hormones, and nitrogen/organonitrogen compounds; (b) apoptosis and cell death; (c) fat cell differentiation and (d) negative regulation of protein kinase.

Full Text

Duke Authors

Cited Authors

  • Hammond, TG; Allen, PL; Birdsall, HH

Published Date

  • December 18, 2018

Published In

Volume / Issue

  • 19 / 12

PubMed ID

  • 30567358

Pubmed Central ID

  • PMC6321533

Electronic International Standard Serial Number (EISSN)

  • 1422-0067

Digital Object Identifier (DOI)

  • 10.3390/ijms19124106


  • eng

Conference Location

  • Switzerland