Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.

Journal Article (Journal Article;Review)

Urologic chronic pelvic pain syndrome (UCPPS), which encompasses interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, is characterized by chronic pain in the pelvic region or genitalia that is often accompanied by urinary frequency and urgency. Despite considerable research, no definite aetiological risk factors or effective treatments have been identified. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network uses a novel integrated strategy to characterize UCPPS as a systemic disorder that potentially involves multiple aetiologies. The first phase, MAPP I, included >1,000 participants who completed an intensive baseline assessment followed by a 12-month observational follow-up period. MAPP I studies showed that UCPPS pain and urinary symptoms co-vary, with only moderate correlation, and should be evaluated separately and that symptom flares are common and can differ considerably in intensity, duration and influence on quality of life. Longitudinal clinical changes in UCPPS correlated with structural and functional brain changes, and many patients experienced global multisensory hypersensitivity. Additionally, UCPPS symptom profiles were distinguishable by biological correlates, such as immune factors. These findings indicate that patients with UCPPS have objective phenotypic abnormalities and distinct biological characteristics, providing a new foundation for the study and clinical management of UCPPS.

Full Text

Duke Authors

Cited Authors

  • Clemens, JQ; Mullins, C; Ackerman, AL; Bavendam, T; van Bokhoven, A; Ellingson, BM; Harte, SE; Kutch, JJ; Lai, HH; Martucci, KT; Moldwin, R; Naliboff, BD; Pontari, MA; Sutcliffe, S; Landis, JR; MAPP Research Network Study Group,

Published Date

  • March 2019

Published In

Volume / Issue

  • 16 / 3

Start / End Page

  • 187 - 200

PubMed ID

  • 30560936

Pubmed Central ID

  • PMC6800057

Electronic International Standard Serial Number (EISSN)

  • 1759-4820

Digital Object Identifier (DOI)

  • 10.1038/s41585-018-0135-5


  • eng

Conference Location

  • England