Balamuthia mandrillaris meningoencephalitis in an immunocompromised patient. Case report.

Journal Article (Journal Article)

Balamuthia mandrillaris is a rare but increasingly recognized cause of amebic encephalitis, yet it remains poorly understood. The condition is almost universally fatal, and due to diagnostic difficulty, most cases are identified postmortem. The authors report a case of Balamuthia amebic encephalitis in a patient with combined variable immunodeficiency in which a rare antemortem diagnosis was made via brain biopsy. Despite broad-spectrum antimicrobial therapy, the outcome was fatal. Such presentations are challenging, and definitive diagnosis may require biopsy in consultation with a skilled neuropathologist.

Full Text

Duke Authors

Cited Authors

  • Kansagra, AP; Menon, JP; Yarbrough, CK; Urbaniak, K; Waters, JD; Borys, E; Jandial, R

Published Date

  • August 2009

Published In

Volume / Issue

  • 111 / 2

Start / End Page

  • 301 - 305

PubMed ID

  • 19025354

International Standard Serial Number (ISSN)

  • 0022-3085

Digital Object Identifier (DOI)

  • 10.3171/2008.9.JNS08718


  • eng

Conference Location

  • United States