The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.

Journal Article (Journal Article)

In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of TMP-SMX in CRE infections.

Full Text

Duke Authors

Cited Authors

  • Luterbach, CL; Boshe, A; Henderson, HI; Cober, E; Richter, SS; Salata, RA; Kalayjian, RC; Watkins, RR; Hujer, AM; Hujer, KM; Rudin, SD; Domitrovic, TN; Doi, Y; Kaye, KS; Evans, S; Fowler, VG; Bonomo, RA; van Duin, D

Published Date

  • January 2019

Published In

Volume / Issue

  • 6 / 1

Start / End Page

  • ofy351 -

PubMed ID

  • 30631796

Pubmed Central ID

  • PMC6324543

International Standard Serial Number (ISSN)

  • 2328-8957

Digital Object Identifier (DOI)

  • 10.1093/ofid/ofy351


  • eng

Conference Location

  • United States