The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.
In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of TMP-SMX in CRE infections.
Luterbach, CL; Boshe, A; Henderson, HI; Cober, E; Richter, SS; Salata, RA; Kalayjian, RC; Watkins, RR; Hujer, AM; Hujer, KM; Rudin, SD; Domitrovic, TN; Doi, Y; Kaye, KS; Evans, S; Fowler, VG; Bonomo, RA; van Duin, D
Volume / Issue
Start / End Page
Pubmed Central ID
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)