Skip to main content

Prevalence and Outcome of HIV-associated Malignancies Among HIV-infected Children Enrolled into Care at Kilimanjaro Christian Medical Center 2006 to 2014: A Hospital-based Retrospective Analytical Study.

Publication ,  Journal Article
Irira, M; Ngocho, JS; Youze, J; Shayo, I; Komba, V; Minja, L; Karia, FP; Bartlett, J; Mmbaga, BT
Published in: J Pediatr Hematol Oncol
January 2020

OBJECTIVE: We aimed to establish the prevalence of human immunodeficiency virus (HIV)-associated malignancies in children attending a care and treatment clinic at Kilimanjaro Christian Medical Centre. MATERIALS AND METHODS: This was a retrospective cross-sectional hospital-based study of children who attended an HIV care and treatment clinic between 2006 and 2014. Children 2 months to 17 years of age were eligible for participation. The data on social demographic and clinical characteristics were extracted from the medical record. A multivariate logistic regression model was developed to determine predictors of HIV-associated malignancies. RESULTS: Medical records from 721 HIV-infected children were reviewed. The median age (interquartile range) at HIV diagnosis was 5.7 (2.0 to 9.4) years. Among them, 34 (4.7%) had HIV-associated malignancies. The most common (n=24, 70.3%) malignancy was the Kaposi sarcoma. Age at HIV diagnosis was significantly associated with HIV-associated malignancies (adjusted odds ratio, 1.2; 95% confidence interval, 1.0-1.3). Among 34 patients with HIV-associated malignancies, 11 (32.4%) died. Seven (20.6%) patients reported complete remission from their malignancies, and outcomes for 6 patients were unknown. CONCLUSIONS: The prevalence of HIV-associated malignancies was high and was associated with late HIV diagnosis. The Kaposi sarcoma was the commonest malignancy. Early HIV diagnosis and treatment in children might reduce HIV-associated malignancies.

Duke Scholars

Published In

J Pediatr Hematol Oncol

DOI

EISSN

1536-3678

Publication Date

January 2020

Volume

42

Issue

1

Start / End Page

69 / 73

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Prevalence
  • Oncology & Carcinogenesis
  • Neoplasms
  • Male
  • Kenya
  • Humans
  • HIV-1
  • HIV Infections
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Irira, M., Ngocho, J. S., Youze, J., Shayo, I., Komba, V., Minja, L., … Mmbaga, B. T. (2020). Prevalence and Outcome of HIV-associated Malignancies Among HIV-infected Children Enrolled into Care at Kilimanjaro Christian Medical Center 2006 to 2014: A Hospital-based Retrospective Analytical Study. J Pediatr Hematol Oncol, 42(1), 69–73. https://doi.org/10.1097/MPH.0000000000001389
Irira, Michael, James S. Ngocho, Joshua Youze, Irene Shayo, Venancia Komba, Linda Minja, Francis P. Karia, John Bartlett, and Blandina T. Mmbaga. “Prevalence and Outcome of HIV-associated Malignancies Among HIV-infected Children Enrolled into Care at Kilimanjaro Christian Medical Center 2006 to 2014: A Hospital-based Retrospective Analytical Study.J Pediatr Hematol Oncol 42, no. 1 (January 2020): 69–73. https://doi.org/10.1097/MPH.0000000000001389.
Irira, Michael, et al. “Prevalence and Outcome of HIV-associated Malignancies Among HIV-infected Children Enrolled into Care at Kilimanjaro Christian Medical Center 2006 to 2014: A Hospital-based Retrospective Analytical Study.J Pediatr Hematol Oncol, vol. 42, no. 1, Jan. 2020, pp. 69–73. Pubmed, doi:10.1097/MPH.0000000000001389.
Irira M, Ngocho JS, Youze J, Shayo I, Komba V, Minja L, Karia FP, Bartlett J, Mmbaga BT. Prevalence and Outcome of HIV-associated Malignancies Among HIV-infected Children Enrolled into Care at Kilimanjaro Christian Medical Center 2006 to 2014: A Hospital-based Retrospective Analytical Study. J Pediatr Hematol Oncol. 2020 Jan;42(1):69–73.

Published In

J Pediatr Hematol Oncol

DOI

EISSN

1536-3678

Publication Date

January 2020

Volume

42

Issue

1

Start / End Page

69 / 73

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Prevalence
  • Oncology & Carcinogenesis
  • Neoplasms
  • Male
  • Kenya
  • Humans
  • HIV-1
  • HIV Infections
  • Female