Early experience with the use of hepatitis C antibody-positive, nucleic acid testing-negative donors in lung transplantation.
Journal Article (Journal Article)
Historically, potential lung donors who have detectable antibodies to hepatitis C virus have been declined by most centers due to concern for possible disease transmission. We sought to evaluate hepatitis C viral transmission rates from donors who were known to be HCV Ab positive but HCV NAT negative. We performed a single-center retrospective review of a prospectively collected database for lung transplant recipients at our center including HCV Ab+NAT- donors (approved January 2017). Donor and recipient demographic data were compiled, and records were queried to ascertain rate of seroconversion. During the study period (1/1/17 to 8/9/17), a total of 64 recipients underwent lung transplantation. Thirteen (20%) donors were HCV Ab+NAT-. All recipients of HCV Ab+NAT- grafts were HCV Ab- at the time of transplant. Recipients of grafts from HCV Ab+NAT- donors underwent protocol NAT at 2 and 12 months and all are NAT- to date. One recipient developed reactive HCV Ab at 6 months post-transplant. Follow-up NAT showed HCV RNA to be undetectable. To date, use of HCV Ab+NAT- donors in lung transplantation has yielded favorable outcomes, with evidence of one transient seroconversion suggesting this practice may increase access to life-saving transplantation to those in need.
Full Text
Duke Authors
Cited Authors
- Watson, J; Mulvihill, MS; Cox, ML; Rich, L; Wolfe, CR; Gray, A; Hartwig, MG
Published Date
- March 2019
Published In
Volume / Issue
- 33 / 3
Start / End Page
- e13476 -
PubMed ID
- 30609162
Pubmed Central ID
- 30609162
Electronic International Standard Serial Number (EISSN)
- 1399-0012
Digital Object Identifier (DOI)
- 10.1111/ctr.13476
Language
- eng
Conference Location
- Denmark