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Genetic variants in the calcium signaling pathway genes are associated with cutaneous melanoma-specific survival.

Publication ,  Journal Article
Wang, X; Liu, H; Xu, Y; Xie, J; Zhu, D; Amos, CI; Fang, S; Lee, JE; Li, X; Nan, H; Song, Y; Wei, Q
Published in: Carcinogenesis
April 29, 2019

Remodeling or deregulation of the calcium signaling pathway is a relevant hallmark of cancer including cutaneous melanoma (CM). In this study, using data from a published genome-wide association study (GWAS) from The University of Texas M.D. Anderson Cancer Center, we assessed the role of 41,377 common single-nucleotide polymorphisms (SNPs) of 167 calcium signaling pathway genes in CM survival. We used another GWAS from Harvard University as the validation dataset. In the single-locus analysis, 1830 SNPs were found to be significantly associated with CM-specific survival (CMSS; P ≤ 0.050 and false-positive report probability ≤ 0.2), of which 9 SNPs were validated in the Harvard study (P ≤ 0.050). Among these, three independent SNPs (i.e. PDE1A rs6750552 T>C, ITPR1 rs6785564 A>G and RYR3 rs2596191 C>A) had a predictive role in CMSS, with a meta-analysis-derived hazards ratio of 1.52 (95% confidence interval = 1.19-1.94, P = 7.21 × 10-4), 0.49 (0.33-0.73, 3.94 × 10-4) and 0.67 (0.53-0.86, 0.0017), respectively. Patients with an increasing number of protective genotypes had remarkably improved CMSS. Additional expression quantitative trait loci analysis showed that these genotypes were also significantly associated with mRNA expression levels of the genes. Taken together, these results may help us to identify prospective biomarkers in the calcium signaling pathway for CM prognosis.

Duke Scholars

Published In

Carcinogenesis

DOI

EISSN

1460-2180

Publication Date

April 29, 2019

Volume

40

Issue

2

Start / End Page

279 / 288

Location

England

Related Subject Headings

  • Young Adult
  • Skin Neoplasms
  • Quantitative Trait Loci
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Melanoma, Cutaneous Malignant
  • Melanoma
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, X., Liu, H., Xu, Y., Xie, J., Zhu, D., Amos, C. I., … Wei, Q. (2019). Genetic variants in the calcium signaling pathway genes are associated with cutaneous melanoma-specific survival. Carcinogenesis, 40(2), 279–288. https://doi.org/10.1093/carcin/bgy188
Wang, Xiaomeng, Hongliang Liu, Yinghui Xu, Jichun Xie, Dakai Zhu, Christopher I. Amos, Shenying Fang, et al. “Genetic variants in the calcium signaling pathway genes are associated with cutaneous melanoma-specific survival.Carcinogenesis 40, no. 2 (April 29, 2019): 279–88. https://doi.org/10.1093/carcin/bgy188.
Wang X, Liu H, Xu Y, Xie J, Zhu D, Amos CI, et al. Genetic variants in the calcium signaling pathway genes are associated with cutaneous melanoma-specific survival. Carcinogenesis. 2019 Apr 29;40(2):279–88.
Wang, Xiaomeng, et al. “Genetic variants in the calcium signaling pathway genes are associated with cutaneous melanoma-specific survival.Carcinogenesis, vol. 40, no. 2, Apr. 2019, pp. 279–88. Pubmed, doi:10.1093/carcin/bgy188.
Wang X, Liu H, Xu Y, Xie J, Zhu D, Amos CI, Fang S, Lee JE, Li X, Nan H, Song Y, Wei Q. Genetic variants in the calcium signaling pathway genes are associated with cutaneous melanoma-specific survival. Carcinogenesis. 2019 Apr 29;40(2):279–288.
Journal cover image

Published In

Carcinogenesis

DOI

EISSN

1460-2180

Publication Date

April 29, 2019

Volume

40

Issue

2

Start / End Page

279 / 288

Location

England

Related Subject Headings

  • Young Adult
  • Skin Neoplasms
  • Quantitative Trait Loci
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Melanoma, Cutaneous Malignant
  • Melanoma
  • Male