Despite the persistent high mortality, many adults are living with chronic heart failure. Recent updates to the clinical guidelines for managing heart failure provide substantive recommendations on how to treat patients with heart failure with preserved ejection fraction or heart failure with reduced ejection fraction. Key changes in these guidelines include 2 new medications, use of biomarkers, a focus on specific comorbidities, and prevention strategies. This report provides recommendations from the updated 2017 guideline for the management of heart failure for nurse practitioners in caring for patients with chronic heart failure.