Irreversible electroporation in a case of pancreatic leiomyosarcoma: a novel weapon versus a rare malignancy?

Journal Article (Journal Article)


Primary pancreatic leiomyosarcoma is an extremely rare entity that needs high clinical suspicion in order to diagnose it at an early stage. Clinical characteristics, diagnosis, and management still remain challenging and controversial, especially in advanced stages, when tumor invades adjacent vessels and organs or gives distant metastases.

Case presentation

Herein, we describe a case of a 57-year-old woman suffering from advanced pancreatic leiomyosarcoma with thrombosis of the superior mesenteric vein, as well as liver lesions which were suspicious for metastasis. Multidisciplinary team decided for upfront chemotherapy to assess tumor response. Follow-up imaging after the completion of chemotherapy led tumor board to decide for subsequent surgical exploration. The patient underwent exploratory laparotomy and irreversible electroporation ablation of the pancreatic tumor. Postoperative course was uneventful, and she was discharged 10 days later with a plan to receive adjuvant therapy. To the best of our knowledge, this is the first case of pancreatic leiomyosarcoma ever reported, treated with this novel technique of irreversible electroporation that could be an alternative and feasible way for the management of these rare malignancies.


In conclusion, primary pancreatic leiomyosarcoma is a rare and highly malignant tumor associated with poor prognosis. Nowadays, R0 surgical resection remains the cornerstone treatment, combined with adjuvant and/or neoadjuvant chemotherapy prior to resection. In the advanced setting, when major vessel invasion and distant metastases occur, chemotherapy along with irreversible electroporation ablation could be a helpful and possibly effective modality for the management of this highly aggressive tumor.

Full Text

Duke Authors

Cited Authors

  • Papalampros, A; Vailas, MG; Deladetsima, I; Moris, D; Sotiropoulou, M; Syllaios, A; Petrou, A; Felekouras, E

Published Date

  • January 5, 2019

Published In

Volume / Issue

  • 17 / 1

Start / End Page

  • 6 -

PubMed ID

  • 30611280

Pubmed Central ID

  • PMC6320590

Electronic International Standard Serial Number (EISSN)

  • 1477-7819

International Standard Serial Number (ISSN)

  • 1477-7819

Digital Object Identifier (DOI)

  • 10.1186/s12957-018-1553-9


  • eng