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Irreversible electroporation in a case of pancreatic leiomyosarcoma: a novel weapon versus a rare malignancy?

Publication ,  Journal Article
Papalampros, A; Vailas, MG; Deladetsima, I; Moris, D; Sotiropoulou, M; Syllaios, A; Petrou, A; Felekouras, E
Published in: World journal of surgical oncology
January 2019

Primary pancreatic leiomyosarcoma is an extremely rare entity that needs high clinical suspicion in order to diagnose it at an early stage. Clinical characteristics, diagnosis, and management still remain challenging and controversial, especially in advanced stages, when tumor invades adjacent vessels and organs or gives distant metastases.Herein, we describe a case of a 57-year-old woman suffering from advanced pancreatic leiomyosarcoma with thrombosis of the superior mesenteric vein, as well as liver lesions which were suspicious for metastasis. Multidisciplinary team decided for upfront chemotherapy to assess tumor response. Follow-up imaging after the completion of chemotherapy led tumor board to decide for subsequent surgical exploration. The patient underwent exploratory laparotomy and irreversible electroporation ablation of the pancreatic tumor. Postoperative course was uneventful, and she was discharged 10 days later with a plan to receive adjuvant therapy. To the best of our knowledge, this is the first case of pancreatic leiomyosarcoma ever reported, treated with this novel technique of irreversible electroporation that could be an alternative and feasible way for the management of these rare malignancies.In conclusion, primary pancreatic leiomyosarcoma is a rare and highly malignant tumor associated with poor prognosis. Nowadays, R0 surgical resection remains the cornerstone treatment, combined with adjuvant and/or neoadjuvant chemotherapy prior to resection. In the advanced setting, when major vessel invasion and distant metastases occur, chemotherapy along with irreversible electroporation ablation could be a helpful and possibly effective modality for the management of this highly aggressive tumor.

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Published In

World journal of surgical oncology

DOI

EISSN

1477-7819

ISSN

1477-7819

Publication Date

January 2019

Volume

17

Issue

1

Start / End Page

6

Related Subject Headings

  • Treatment Outcome
  • Rare Diseases
  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Leiomyosarcoma
  • Humans
  • Female
  • Electroporation
  • 3211 Oncology and carcinogenesis
 

Citation

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Papalampros, A., Vailas, M. G., Deladetsima, I., Moris, D., Sotiropoulou, M., Syllaios, A., … Felekouras, E. (2019). Irreversible electroporation in a case of pancreatic leiomyosarcoma: a novel weapon versus a rare malignancy? World Journal of Surgical Oncology, 17(1), 6. https://doi.org/10.1186/s12957-018-1553-9
Papalampros, Alexandros, Michail G. Vailas, Ioanna Deladetsima, Demetrios Moris, Maria Sotiropoulou, Athanasios Syllaios, Athanasios Petrou, and Evangelos Felekouras. “Irreversible electroporation in a case of pancreatic leiomyosarcoma: a novel weapon versus a rare malignancy?World Journal of Surgical Oncology 17, no. 1 (January 2019): 6. https://doi.org/10.1186/s12957-018-1553-9.
Papalampros A, Vailas MG, Deladetsima I, Moris D, Sotiropoulou M, Syllaios A, et al. Irreversible electroporation in a case of pancreatic leiomyosarcoma: a novel weapon versus a rare malignancy? World journal of surgical oncology. 2019 Jan;17(1):6.
Papalampros, Alexandros, et al. “Irreversible electroporation in a case of pancreatic leiomyosarcoma: a novel weapon versus a rare malignancy?World Journal of Surgical Oncology, vol. 17, no. 1, Jan. 2019, p. 6. Epmc, doi:10.1186/s12957-018-1553-9.
Papalampros A, Vailas MG, Deladetsima I, Moris D, Sotiropoulou M, Syllaios A, Petrou A, Felekouras E. Irreversible electroporation in a case of pancreatic leiomyosarcoma: a novel weapon versus a rare malignancy? World journal of surgical oncology. 2019 Jan;17(1):6.
Journal cover image

Published In

World journal of surgical oncology

DOI

EISSN

1477-7819

ISSN

1477-7819

Publication Date

January 2019

Volume

17

Issue

1

Start / End Page

6

Related Subject Headings

  • Treatment Outcome
  • Rare Diseases
  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Leiomyosarcoma
  • Humans
  • Female
  • Electroporation
  • 3211 Oncology and carcinogenesis