Obestatin and adropin in Prader-Willi syndrome and nonsyndromic obesity: Associations with weight, BMI-z, and HOMA-IR.

Journal Article (Journal Article)

The roles of obestatin and adropin in paediatric obesity are poorly understood. We compared obestatin and adropin concentrations in younger (n = 21) and older children (n = 14) with Prader-Willi syndrome (PWS) and age and BMI-z-matched controls (n = 31). Fasting plasma obestatin and adropin were higher in younger children with PWS than controls; adropin was also higher in older children with PWS. Growth hormone treatment had no effects on obestatin or adropin in PWS. The ratio of ghrelin to obestatin declined from early to late childhood but was higher in older PWS than older controls. Adropin correlated with fasting glucose in the PWS group only. Changes in the ratio of ghrelin to obestatin may suggest changes in the processing of preproghrelin to ghrelin and obestatin during development and differential processing of preproghrelin in PWS.

Full Text

Duke Authors

Cited Authors

  • Orsso, CE; Butler, AA; Muehlbauer, MJ; Cui, HN; Rubin, DA; Pakseresht, M; Butler, MG; Prado, CM; Freemark, M; Haqq, AM

Published Date

  • May 2019

Published In

Volume / Issue

  • 14 / 5

Start / End Page

  • e12493 -

PubMed ID

  • 30589518

Pubmed Central ID

  • PMC7456601

Electronic International Standard Serial Number (EISSN)

  • 2047-6310

Digital Object Identifier (DOI)

  • 10.1111/ijpo.12493


  • eng

Conference Location

  • England