K-Sample comparisons using propensity analysis.

Journal Article (Journal Article)

In this paper, we investigate K-group comparisons on survival endpoints for observational studies. In clinical databases for observational studies, treatment for patients are chosen with probabilities varying depending on their baseline characteristics. This often results in noncomparable treatment groups because of imbalance in baseline characteristics of patients among treatment groups. In order to overcome this issue, we conduct propensity analysis and match the subjects with similar propensity scores across treatment groups or compare weighted group means (or weighted survival curves for censored outcome variables) using the inverse probability weighting (IPW). To this end, multinomial logistic regression has been a popular propensity analysis method to estimate the weights. We propose to use decision tree method as an alternative propensity analysis due to its simplicity and robustness. We also propose IPW rank statistics, called Dunnett-type test and ANOVA-type test, to compare 3 or more treatment groups on survival endpoints. Using simulations, we evaluate the finite sample performance of the weighted rank statistics combined with these propensity analysis methods. We demonstrate these methods with a real data example. The IPW method also allows us for unbiased estimation of population parameters of each treatment group. In this paper, we limit our discussions to survival outcomes, but all the methods can be easily modified for any type of outcomes, such as binary or continuous variables.

Full Text

Duke Authors

Cited Authors

  • Jung, S-H; Chi, SA; Ahn, HJ

Published Date

  • May 2019

Published In

Volume / Issue

  • 61 / 3

Start / End Page

  • 698 - 713

PubMed ID

  • 30614546

Pubmed Central ID

  • PMC6461520

Electronic International Standard Serial Number (EISSN)

  • 1521-4036

Digital Object Identifier (DOI)

  • 10.1002/bimj.201800049

Language

  • eng

Conference Location

  • Germany