Trajectories of functional ability over the life course: a conceptual model of the interaction of stressor-induced functional loss and resilience.


Journal Article

Understanding the factors that influence functional ability over the life course is integral to identifying clinical and public health policies to facilitate successful aging. The World Health Organization has advocated a conceptual framework to clarify the policy discussion. We have sought to translate this general framework into an explicit system dynamics model of the interaction of physiological loss, stressors and endogenous responses to produce a familiar variety of trajectories of functional ability over the life courses. Simulation experiments were implemented for both a 30-month duration with only one major stressor; and for the life course with an initial major stressor and subsequent stressors determined by the level of functional ability. For both contexts, variations in the few parameters in the scenarios led to a realistic range of trajectories of function over time.

Full Text

Duke Authors

Cited Authors

  • Matchar, DB; Ansah, JP; Koh, V; Whitson, HE

Published Date

  • October 2018

Published In

Volume / Issue

  • 34 / 4

Start / End Page

  • 481 - 502

PubMed ID

  • 33041497

Pubmed Central ID

  • 33041497

International Standard Serial Number (ISSN)

  • 0883-7066

Digital Object Identifier (DOI)

  • 10.1002/sdr.1611


  • eng

Conference Location

  • United States