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The effect of laparoscopic gastric banding surgery on plasma levels of appetite-control, insulinotropic, and digestive hormones.

Publication ,  Journal Article
Shak, JR; Roper, J; Perez-Perez, GI; Tseng, C-H; Francois, F; Gamagaris, Z; Patterson, C; Weinshel, E; Fielding, GA; Ren, C; Blaser, MJ
Published in: Obes Surg
September 2008

BACKGROUND: We hypothesized that laparoscopic adjustable gastric banding (LAGB) reduces weight and modulates ghrelin production, but largely spares gastrointestinal endocrine function. To examine this hypothesis, we determined plasma concentrations of appetite-control, insulinotropic, and digestive hormones in relation to LAGB. METHODS: Twenty-four patients undergoing LAGB were prospectively enrolled. Body mass index (BMI) was measured and blood samples obtained at baseline and 6 and 12 months post-surgery. Plasma concentrations of leptin, acylated and total ghrelin, pancreatic polypeptide (PP), insulin, glucose-dependent insulinotropic peptide (GIP), active glucagon-like peptide-1 (GLP-1), gastrin, and pepsinogens I and II were measured using enzyme-linked immunoassays. RESULTS: Median percent excess weight loss (%EWL) over 12 months was 45.7% with median BMI decreasing from 43.2 at baseline to 33.8 at 12 months post-surgery (p < 0.001). Median leptin levels decreased from 19.7 ng/ml at baseline to 6.9 ng/ml at 12 months post-surgery (p < 0.001). In contrast, plasma levels of acylated and total ghrelin, PP, insulin, GIP, GLP-1, gastrin, and pepsinogen I did not change in relation to surgery (p > 0.05). Pepsinogen II levels were significantly lower 6 months after LAGB but returned to baseline levels by 12 months. CONCLUSIONS: LAGB yielded substantial %EWL and a proportional decrease in plasma leptin. Our results support the hypothesis that LAGB works in part by suppressing the rise in ghrelin that normally accompanies weight loss. Unchanged concentrations of insulinotropic and digestive hormones suggest that gastrointestinal endocrine function is largely maintained in the long term.

Duke Scholars

Published In

Obes Surg

DOI

ISSN

0960-8923

Publication Date

September 2008

Volume

18

Issue

9

Start / End Page

1089 / 1096

Location

United States

Related Subject Headings

  • Weight Loss
  • Time Factors
  • Surgery
  • Prospective Studies
  • Peptide Hormones
  • Obesity, Morbid
  • Middle Aged
  • Male
  • Laparoscopy
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Shak, J. R., Roper, J., Perez-Perez, G. I., Tseng, C.-H., Francois, F., Gamagaris, Z., … Blaser, M. J. (2008). The effect of laparoscopic gastric banding surgery on plasma levels of appetite-control, insulinotropic, and digestive hormones. Obes Surg, 18(9), 1089–1096. https://doi.org/10.1007/s11695-008-9454-6
Shak, Joshua R., Jatin Roper, Guillermo I. Perez-Perez, Chi-hong Tseng, Fritz Francois, Zoi Gamagaris, Carlie Patterson, et al. “The effect of laparoscopic gastric banding surgery on plasma levels of appetite-control, insulinotropic, and digestive hormones.Obes Surg 18, no. 9 (September 2008): 1089–96. https://doi.org/10.1007/s11695-008-9454-6.
Shak JR, Roper J, Perez-Perez GI, Tseng C-H, Francois F, Gamagaris Z, et al. The effect of laparoscopic gastric banding surgery on plasma levels of appetite-control, insulinotropic, and digestive hormones. Obes Surg. 2008 Sep;18(9):1089–96.
Shak, Joshua R., et al. “The effect of laparoscopic gastric banding surgery on plasma levels of appetite-control, insulinotropic, and digestive hormones.Obes Surg, vol. 18, no. 9, Sept. 2008, pp. 1089–96. Pubmed, doi:10.1007/s11695-008-9454-6.
Shak JR, Roper J, Perez-Perez GI, Tseng C-H, Francois F, Gamagaris Z, Patterson C, Weinshel E, Fielding GA, Ren C, Blaser MJ. The effect of laparoscopic gastric banding surgery on plasma levels of appetite-control, insulinotropic, and digestive hormones. Obes Surg. 2008 Sep;18(9):1089–1096.
Journal cover image

Published In

Obes Surg

DOI

ISSN

0960-8923

Publication Date

September 2008

Volume

18

Issue

9

Start / End Page

1089 / 1096

Location

United States

Related Subject Headings

  • Weight Loss
  • Time Factors
  • Surgery
  • Prospective Studies
  • Peptide Hormones
  • Obesity, Morbid
  • Middle Aged
  • Male
  • Laparoscopy
  • Humans