Botulinum toxin: From molecule to clinic

Book Section

Treatment with botulinum toxin has fast become the mainstay for the management of focal dystonias. Its wide utility lies in the fact that, by harnessing the chemical denervation properties of this toxin, one can functionally weaken the endpoint of dystonia irrespective of its etiology. The goal of this chapter is to summarize the molecular and cellular mechanisms of botulinum toxin, highlighting areas in need of further investigation and practical treatment issues in need of optimization. Such an understanding of the principles of botulinum toxin action is paramount to developing the next generation of therapeutic agents.

Duke Authors

Cited Authors

  • Calakos, N

Published Date

  • January 1, 2006

Book Title

  • Handbook of Dystonia

Start / End Page

  • 343 - 354

International Standard Book Number 10 (ISBN-10)

  • 0849376122

International Standard Book Number 13 (ISBN-13)

  • 9780849376122

Citation Source

  • Scopus