Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways.

Published online

Journal Article (Review)

Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These assays have been developed in microbial systems that provide the advantages of genetic and molecular reporters that can readily be manipulated. Cellular assays comprise genetic, molecular, and cytological reporters. The assays are powerful tools but each comes with its particular advantages and limitations. Here the most commonly used assays are reviewed, discussed, and presented as the guidelines for future studies.

Full Text

Duke Authors

Cited Authors

  • Klein, HL; Bańćinskaja, G; Che, J; Cheblal, A; Elango, R; Epshtein, A; Fitzgerald, DM; Gómez-González, B; Khan, SR; Kumar, S; Leland, BA; Marie, L; Mei, Q; Miné-Hattab, J; Piotrowska, A; Polleys, EJ; Putnam, CD; Radchenko, EA; Saada, AA; Sakofsky, CJ; Shim, EY; Stracy, M; Xia, J; Yan, Z; Yin, Y; Aguilera, A; Argueso, JL; Freudenreich, CH; Gasser, SM; Gordenin, DA; Haber, JE; Ira, G; Jinks-Robertson, S; King, MC; Kolodner, RD; Kuzminov, A; Lambert, SA; Lee, SE; Miller, KM; Mirkin, SM; Petes, TD; Rosenberg, SM; Rothstein, R; Symington, LS; Zawadzki, P; Kim, N; Lisby, M; Malkova, A

Published Date

  • January 7, 2019

Published In

Volume / Issue

  • 6 / 1

Start / End Page

  • 1 - 64

PubMed ID

  • 30652105

Pubmed Central ID

  • 30652105

International Standard Serial Number (ISSN)

  • 2311-2638

Digital Object Identifier (DOI)

  • 10.15698/mic2019.01.664

Language

  • eng

Conference Location

  • Austria