Skip to main content

Nonhuman primate species as models of human bacterial sepsis.

Publication ,  Journal Article
Chen, L; Welty-Wolf, KE; Kraft, BD
Published in: Lab Anim (NY)
February 2019

Sepsis involves a disordered host response to systemic infection leading to high morbidity and mortality. Despite intense research, targeted sepsis therapies beyond antibiotics have remained elusive. The cornerstone of sepsis research is the development of animal models to mimic human bacterial infections and test novel pharmacologic targets. Nonhuman primates (NHPs) have served as an attractive, but expensive, animal to model human bacterial infections due to their nearly identical cardiopulmonary anatomy and physiology, as well as host response to infection. Several NHP species have provided substantial insight into sepsis-mediated inflammation, endothelial dysfunction, acute lung injury, and multi-organ failure. The use of NHPs has usually focused on translating therapies from early preclinical models to human clinical trials. However, despite successful sepsis interventions in NHP models, there are still no FDA-approved sepsis therapies. This review highlights major NHP models of bacterial sepsis and their relevance to clinical medicine.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Lab Anim (NY)

DOI

EISSN

1548-4475

Publication Date

February 2019

Volume

48

Issue

2

Start / End Page

57 / 65

Location

United States

Related Subject Headings

  • Veterinary Sciences
  • Primates
  • Humans
  • Disease Models, Animal
  • Bacteremia
  • Anti-Bacterial Agents
  • Animals
  • 3009 Veterinary sciences
  • 0707 Veterinary Sciences
  • 0699 Other Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chen, L., Welty-Wolf, K. E., & Kraft, B. D. (2019). Nonhuman primate species as models of human bacterial sepsis. Lab Anim (NY), 48(2), 57–65. https://doi.org/10.1038/s41684-018-0217-2
Chen, Lingye, Karen E. Welty-Wolf, and Bryan D. Kraft. “Nonhuman primate species as models of human bacterial sepsis.Lab Anim (NY) 48, no. 2 (February 2019): 57–65. https://doi.org/10.1038/s41684-018-0217-2.
Chen L, Welty-Wolf KE, Kraft BD. Nonhuman primate species as models of human bacterial sepsis. Lab Anim (NY). 2019 Feb;48(2):57–65.
Chen, Lingye, et al. “Nonhuman primate species as models of human bacterial sepsis.Lab Anim (NY), vol. 48, no. 2, Feb. 2019, pp. 57–65. Pubmed, doi:10.1038/s41684-018-0217-2.
Chen L, Welty-Wolf KE, Kraft BD. Nonhuman primate species as models of human bacterial sepsis. Lab Anim (NY). 2019 Feb;48(2):57–65.

Published In

Lab Anim (NY)

DOI

EISSN

1548-4475

Publication Date

February 2019

Volume

48

Issue

2

Start / End Page

57 / 65

Location

United States

Related Subject Headings

  • Veterinary Sciences
  • Primates
  • Humans
  • Disease Models, Animal
  • Bacteremia
  • Anti-Bacterial Agents
  • Animals
  • 3009 Veterinary sciences
  • 0707 Veterinary Sciences
  • 0699 Other Biological Sciences