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Acute Vaso-Occlusive Pain is Temporally Associated with the Onset of Menstruation in Women with Sickle Cell Disease.

Publication ,  Journal Article
Sharma, D; Day, ME; Stimpson, S-J; Rodeghier, M; Ghafuri, D; Callaghan, M; Zaidi, AU; Hannan, B; Kassim, A; Zempsky, W; Wellons, M; James, A ...
Published in: J Womens Health (Larchmt)
February 2019

BACKGROUND: Acute vaso-occlusive pain episodes in sickle cell disease (SCD) are associated with increased rates of hospitalization and early mortality. Despite the observation that women have higher rates of acute vaso-occlusive pain episodes than men, sex-specific risk factors for acute vaso-occlusive pain have not been identified. We tested the hypothesis that acute vaso-occlusive pain is temporally associated with the onset of menstruation in women with SCD. METHODS: Initially, using a cross-sectional study design, we administered questionnaires, including validated measures of SCD pain frequency and severity within the last 30 days, as well as menstrual symptoms in a discovery group (n = 103). We then confirmed our findings by administering the same questionnaires online in a replication group (n = 118). A validated questionnaire was used to define dysmenorrhea. RESULTS: In the initial discovery group, 28% (29 of 103) reported acute vaso-occlusive pain episodes temporally associated with menstruation, and 72% (74 of 103) did not. Of the 29 reporting acute vaso-occlusive pain associated with menstruation, 90% (26) and 10% (3) did and did not meet criteria for dysmenorrhea, respectively. In the replication group, 36% (43 of 118) reported acute vaso-occlusive pain temporally associated with menstruation. Of the 43 reporting acute vaso-occlusive pain associated with menstruation, 60% (26) and 40% (17) did and did not meet criteria for dysmenorrhea, respectively. CONCLUSIONS: In both the discovery and replication groups, we demonstrate that acute vaso-occlusive pain is temporally associated with the onset of menstruation that women with SCD can distinguish from dysmenorrhea.

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Published In

J Womens Health (Larchmt)

DOI

EISSN

1931-843X

Publication Date

February 2019

Volume

28

Issue

2

Start / End Page

162 / 169

Location

United States

Related Subject Headings

  • Young Adult
  • Surveys and Questionnaires
  • Sex Characteristics
  • Public Health
  • Menstruation
  • Humans
  • Female
  • Dysmenorrhea
  • Cross-Sectional Studies
  • Anemia, Sickle Cell
 

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Sharma, D., Day, M. E., Stimpson, S.-J., Rodeghier, M., Ghafuri, D., Callaghan, M., … DeBaun, M. R. (2019). Acute Vaso-Occlusive Pain is Temporally Associated with the Onset of Menstruation in Women with Sickle Cell Disease. J Womens Health (Larchmt), 28(2), 162–169. https://doi.org/10.1089/jwh.2018.7147
Sharma, Deva, Melissa E. Day, Sarah-Jo Stimpson, Mark Rodeghier, Djamila Ghafuri, Michael Callaghan, Ahmar Urooj Zaidi, et al. “Acute Vaso-Occlusive Pain is Temporally Associated with the Onset of Menstruation in Women with Sickle Cell Disease.J Womens Health (Larchmt) 28, no. 2 (February 2019): 162–69. https://doi.org/10.1089/jwh.2018.7147.
Sharma D, Day ME, Stimpson S-J, Rodeghier M, Ghafuri D, Callaghan M, et al. Acute Vaso-Occlusive Pain is Temporally Associated with the Onset of Menstruation in Women with Sickle Cell Disease. J Womens Health (Larchmt). 2019 Feb;28(2):162–9.
Sharma, Deva, et al. “Acute Vaso-Occlusive Pain is Temporally Associated with the Onset of Menstruation in Women with Sickle Cell Disease.J Womens Health (Larchmt), vol. 28, no. 2, Feb. 2019, pp. 162–69. Pubmed, doi:10.1089/jwh.2018.7147.
Sharma D, Day ME, Stimpson S-J, Rodeghier M, Ghafuri D, Callaghan M, Zaidi AU, Hannan B, Kassim A, Zempsky W, Wellons M, James A, Bruehl S, DeBaun MR. Acute Vaso-Occlusive Pain is Temporally Associated with the Onset of Menstruation in Women with Sickle Cell Disease. J Womens Health (Larchmt). 2019 Feb;28(2):162–169.
Journal cover image

Published In

J Womens Health (Larchmt)

DOI

EISSN

1931-843X

Publication Date

February 2019

Volume

28

Issue

2

Start / End Page

162 / 169

Location

United States

Related Subject Headings

  • Young Adult
  • Surveys and Questionnaires
  • Sex Characteristics
  • Public Health
  • Menstruation
  • Humans
  • Female
  • Dysmenorrhea
  • Cross-Sectional Studies
  • Anemia, Sickle Cell