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Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.

Publication ,  Journal Article
Liu, X; Nemeth, DP; McKim, DB; Zhu, L; DiSabato, DJ; Berdysz, O; Gorantla, G; Oliver, B; Witcher, KG; Wang, Y; Negray, CE; Vegesna, RS ...
Published in: Immunity
February 2019

Interleukin-1 (IL-1) signaling is important for multiple potentially pathogenic processes in the central nervous system (CNS), but the cell-type-specific roles of IL-1 signaling are unclear. We used a genetic knockin reporter system in mice to track and reciprocally delete or express IL-1 receptor 1 (IL-1R1) in specific cell types, including endothelial cells, ventricular cells, peripheral myeloid cells, microglia, astrocytes, and neurons. We found that endothelial IL-1R1 was necessary and sufficient for mediating sickness behavior and drove leukocyte recruitment to the CNS and impaired neurogenesis, whereas ventricular IL-1R1 was critical for monocyte recruitment to the CNS. Although microglia did not express IL-1R1, IL-1 stimulation of endothelial cells led to the induction of IL-1 in microglia. Together, these findings describe the structure and functions of the brain's IL-1R1-expressing system and lay a foundation for the dissection and identification of IL-1R1 signaling pathways in the pathogenesis of CNS diseases.

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Published In

Immunity

DOI

EISSN

1097-4180

ISSN

1074-7613

Publication Date

February 2019

Volume

50

Issue

2

Start / End Page

317 / 333.e6

Related Subject Headings

  • Signal Transduction
  • Receptors, Interleukin-1 Type I
  • Neurons
  • Neuroimmunomodulation
  • Microglia
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Interleukin-1
  • Immunology
  • Endothelial Cells
 

Citation

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Chicago
ICMJE
MLA
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Liu, X., Nemeth, D. P., McKim, D. B., Zhu, L., DiSabato, D. J., Berdysz, O., … Quan, N. (2019). Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities. Immunity, 50(2), 317-333.e6. https://doi.org/10.1016/j.immuni.2018.12.012
Liu, Xiaoyu, Daniel P. Nemeth, Daniel B. McKim, Ling Zhu, Damon J. DiSabato, Olimpia Berdysz, Gowthami Gorantla, et al. “Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.Immunity 50, no. 2 (February 2019): 317-333.e6. https://doi.org/10.1016/j.immuni.2018.12.012.
Liu X, Nemeth DP, McKim DB, Zhu L, DiSabato DJ, Berdysz O, et al. Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities. Immunity. 2019 Feb;50(2):317-333.e6.
Liu, Xiaoyu, et al. “Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.Immunity, vol. 50, no. 2, Feb. 2019, pp. 317-333.e6. Epmc, doi:10.1016/j.immuni.2018.12.012.
Liu X, Nemeth DP, McKim DB, Zhu L, DiSabato DJ, Berdysz O, Gorantla G, Oliver B, Witcher KG, Wang Y, Negray CE, Vegesna RS, Sheridan JF, Godbout JP, Robson MJ, Blakely RD, Popovich PG, Bilbo SD, Quan N. Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities. Immunity. 2019 Feb;50(2):317-333.e6.
Journal cover image

Published In

Immunity

DOI

EISSN

1097-4180

ISSN

1074-7613

Publication Date

February 2019

Volume

50

Issue

2

Start / End Page

317 / 333.e6

Related Subject Headings

  • Signal Transduction
  • Receptors, Interleukin-1 Type I
  • Neurons
  • Neuroimmunomodulation
  • Microglia
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Interleukin-1
  • Immunology
  • Endothelial Cells