Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.

Published

Journal Article

Interleukin-1 (IL-1) signaling is important for multiple potentially pathogenic processes in the central nervous system (CNS), but the cell-type-specific roles of IL-1 signaling are unclear. We used a genetic knockin reporter system in mice to track and reciprocally delete or express IL-1 receptor 1 (IL-1R1) in specific cell types, including endothelial cells, ventricular cells, peripheral myeloid cells, microglia, astrocytes, and neurons. We found that endothelial IL-1R1 was necessary and sufficient for mediating sickness behavior and drove leukocyte recruitment to the CNS and impaired neurogenesis, whereas ventricular IL-1R1 was critical for monocyte recruitment to the CNS. Although microglia did not express IL-1R1, IL-1 stimulation of endothelial cells led to the induction of IL-1 in microglia. Together, these findings describe the structure and functions of the brain's IL-1R1-expressing system and lay a foundation for the dissection and identification of IL-1R1 signaling pathways in the pathogenesis of CNS diseases.

Full Text

Duke Authors

Cited Authors

  • Liu, X; Nemeth, DP; McKim, DB; Zhu, L; DiSabato, DJ; Berdysz, O; Gorantla, G; Oliver, B; Witcher, KG; Wang, Y; Negray, CE; Vegesna, RS; Sheridan, JF; Godbout, JP; Robson, MJ; Blakely, RD; Popovich, PG; Bilbo, SD; Quan, N

Published Date

  • February 2019

Published In

Volume / Issue

  • 50 / 2

Start / End Page

  • 317 - 333.e6

PubMed ID

  • 30683620

Pubmed Central ID

  • 30683620

Electronic International Standard Serial Number (EISSN)

  • 1097-4180

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2018.12.012

Language

  • eng