Interneurons from embryonic development to cell-based therapy.

Published

Journal Article (Review)

Many neurologic and psychiatric disorders are marked by imbalances between neural excitation and inhibition. In the cerebral cortex, inhibition is mediated largely by GABAergic (γ-aminobutyric acid-secreting) interneurons, a cell type that originates in the embryonic ventral telencephalon and populates the cortex through long-distance tangential migration. Remarkably, when transplanted from embryos or in vitro culture preparations, immature interneurons disperse and integrate into host brain circuits, both in the cerebral cortex and in other regions of the central nervous system. These features make interneuron transplantation a powerful tool for the study of neurodevelopmental processes such as cell specification, cell death, and cortical plasticity. Moreover, interneuron transplantation provides a novel strategy for modifying neural circuits in rodent models of epilepsy, Parkinson's disease, mood disorders, and chronic pain.

Full Text

Duke Authors

Cited Authors

  • Southwell, DG; Nicholas, CR; Basbaum, AI; Stryker, MP; Kriegstein, AR; Rubenstein, JL; Alvarez-Buylla, A

Published Date

  • April 11, 2014

Published In

Volume / Issue

  • 344 / 6180

Start / End Page

  • 1240622 -

PubMed ID

  • 24723614

Pubmed Central ID

  • 24723614

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.1240622

Language

  • eng

Conference Location

  • United States