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Cortical plasticity induced by inhibitory neuron transplantation.

Publication ,  Journal Article
Southwell, DG; Froemke, RC; Alvarez-Buylla, A; Stryker, MP; Gandhi, SP
Published in: Science
February 26, 2010

Critical periods are times of pronounced brain plasticity. During a critical period in the postnatal development of the visual cortex, the occlusion of one eye triggers a rapid reorganization of neuronal responses, a process known as ocular dominance plasticity. We have shown that the transplantation of inhibitory neurons induces ocular dominance plasticity after the critical period. Transplanted inhibitory neurons receive excitatory synapses, make inhibitory synapses onto host cortical neurons, and promote plasticity when they reach a cellular age equivalent to that of endogenous inhibitory neurons during the normal critical period. These findings suggest that ocular dominance plasticity is regulated by the execution of a maturational program intrinsic to inhibitory neurons. By inducing plasticity, inhibitory neuron transplantation may facilitate brain repair.

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Published In

Science

DOI

EISSN

1095-9203

Publication Date

February 26, 2010

Volume

327

Issue

5969

Start / End Page

1145 / 1148

Location

United States

Related Subject Headings

  • Visual Cortex
  • Synapses
  • Sensory Deprivation
  • Prosencephalon
  • Neurons
  • Neuronal Plasticity
  • Neural Inhibition
  • Mice, Inbred C57BL
  • Mice
  • General Science & Technology
 

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Southwell, D. G., Froemke, R. C., Alvarez-Buylla, A., Stryker, M. P., & Gandhi, S. P. (2010). Cortical plasticity induced by inhibitory neuron transplantation. Science, 327(5969), 1145–1148. https://doi.org/10.1126/science.1183962
Southwell, Derek G., Robert C. Froemke, Arturo Alvarez-Buylla, Michael P. Stryker, and Sunil P. Gandhi. “Cortical plasticity induced by inhibitory neuron transplantation.Science 327, no. 5969 (February 26, 2010): 1145–48. https://doi.org/10.1126/science.1183962.
Southwell DG, Froemke RC, Alvarez-Buylla A, Stryker MP, Gandhi SP. Cortical plasticity induced by inhibitory neuron transplantation. Science. 2010 Feb 26;327(5969):1145–8.
Southwell, Derek G., et al. “Cortical plasticity induced by inhibitory neuron transplantation.Science, vol. 327, no. 5969, Feb. 2010, pp. 1145–48. Pubmed, doi:10.1126/science.1183962.
Southwell DG, Froemke RC, Alvarez-Buylla A, Stryker MP, Gandhi SP. Cortical plasticity induced by inhibitory neuron transplantation. Science. 2010 Feb 26;327(5969):1145–1148.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

February 26, 2010

Volume

327

Issue

5969

Start / End Page

1145 / 1148

Location

United States

Related Subject Headings

  • Visual Cortex
  • Synapses
  • Sensory Deprivation
  • Prosencephalon
  • Neurons
  • Neuronal Plasticity
  • Neural Inhibition
  • Mice, Inbred C57BL
  • Mice
  • General Science & Technology