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Genetic Variants Associated With Vincristine-Induced Peripheral Neuropathy in Two Populations of Children With Acute Lymphoblastic Leukemia.

Publication ,  Journal Article
Li, L; Sajdyk, T; Smith, EML; Chang, CW; Li, C; Ho, RH; Hutchinson, R; Wells, E; Skiles, JL; Winick, N; Martin, PL; Renbarger, JL
Published in: Clin Pharmacol Ther
June 2019

Vincristine is one of the core chemotherapy agents used in the treatment of pediatric acute lymphoblastic leukemia (ALL). However, one of the major toxicities resulting from vincristine exposure is vincristine-induced peripheral neuropathy (VIPN). When VIPN results in significant morbidity, the vincristine dose may need to be reduced, thus potentially decreasing the effectiveness of treatment. To date, there are no robust biomarkers used clinically to determine which patients will be at risk for worse neuropathy. The current study included genomewide association study (GWAS) in two independent cohorts: Pediatric Oncology Group (POG) ALL trials and a multicenter study based at Indiana University in children with ALL. A meta-analysis of the cohorts identified two single-nucleotide polymorphisms (SNPs), rs1045644 and rs7963521, as being significantly (P value threshold 0.05/4749 = 1.05E-05) associated with neuropathy. Subsequently these SNPs may be effective biomarkers of VIPN in children with ALL.

Duke Scholars

Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

June 2019

Volume

105

Issue

6

Start / End Page

1421 / 1428

Location

United States

Related Subject Headings

  • Young Adult
  • Vincristine
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Polymorphism, Single Nucleotide
  • Pharmacology & Pharmacy
  • Peripheral Nervous System Diseases
  • Male
  • Infant
  • Humans
  • Genome-Wide Association Study
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, L., Sajdyk, T., Smith, E. M. L., Chang, C. W., Li, C., Ho, R. H., … Renbarger, J. L. (2019). Genetic Variants Associated With Vincristine-Induced Peripheral Neuropathy in Two Populations of Children With Acute Lymphoblastic Leukemia. Clin Pharmacol Ther, 105(6), 1421–1428. https://doi.org/10.1002/cpt.1324
Li, Lang, Tammy Sajdyk, Ellen M. L. Smith, Chien Wei Chang, Claire Li, Richard H. Ho, Raymond Hutchinson, et al. “Genetic Variants Associated With Vincristine-Induced Peripheral Neuropathy in Two Populations of Children With Acute Lymphoblastic Leukemia.Clin Pharmacol Ther 105, no. 6 (June 2019): 1421–28. https://doi.org/10.1002/cpt.1324.
Li L, Sajdyk T, Smith EML, Chang CW, Li C, Ho RH, et al. Genetic Variants Associated With Vincristine-Induced Peripheral Neuropathy in Two Populations of Children With Acute Lymphoblastic Leukemia. Clin Pharmacol Ther. 2019 Jun;105(6):1421–8.
Li, Lang, et al. “Genetic Variants Associated With Vincristine-Induced Peripheral Neuropathy in Two Populations of Children With Acute Lymphoblastic Leukemia.Clin Pharmacol Ther, vol. 105, no. 6, June 2019, pp. 1421–28. Pubmed, doi:10.1002/cpt.1324.
Li L, Sajdyk T, Smith EML, Chang CW, Li C, Ho RH, Hutchinson R, Wells E, Skiles JL, Winick N, Martin PL, Renbarger JL. Genetic Variants Associated With Vincristine-Induced Peripheral Neuropathy in Two Populations of Children With Acute Lymphoblastic Leukemia. Clin Pharmacol Ther. 2019 Jun;105(6):1421–1428.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

June 2019

Volume

105

Issue

6

Start / End Page

1421 / 1428

Location

United States

Related Subject Headings

  • Young Adult
  • Vincristine
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Polymorphism, Single Nucleotide
  • Pharmacology & Pharmacy
  • Peripheral Nervous System Diseases
  • Male
  • Infant
  • Humans
  • Genome-Wide Association Study