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Mendelian randomization provides support for obesity as a risk factor for meningioma.

Publication ,  Journal Article
Takahashi, H; Cornish, AJ; Sud, A; Law, PJ; Disney-Hogg, L; Calvocoressi, L; Lu, L; Hansen, HM; Smirnov, I; Walsh, KM; Schramm, J; Hoffmann, P ...
Published in: Sci Rep
January 22, 2019

Little is known about the causes of meningioma. Obesity and obesity-related traits have been reported in several epidemiological observational studies to be risk factors for meningioma. We performed an analysis of genetic variants associated with obesity-related traits to assess the relationship with meningioma risk using Mendelian randomization (MR), an approach unaffected by biases from temporal variability and reverse causation that might have affected earlier investigations. We considered 11 obesity-related traits, identified genetic instruments for these factors, and assessed their association with meningioma risk using data from a genome-wide association study comprising 1,606 meningioma patients and 9,823 controls. To evaluate the causal relationship between the obesity-related traits and meningioma risk, we consider the estimated odds ratio (OR) of meningioma for each genetic instrument. We identified positive associations between body mass index (odds ratio [ORSD] = 1.27, 95% confidence interval [CI] = 1.03-1.56, P = 0.028) and body fat percentage (ORSD = 1.28, 95% CI = 1.01-1.63, P = 0.042) with meningioma risk, albeit non-significant after correction for multiple testing. Associations for basal metabolic rate, diastolic blood pressure, fasting glucose, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, systolic blood pressure, total cholesterol, triglycerides and waist circumference with risk of meningioma were non-significant. Our analysis provides additional support for obesity being associated with an increased risk of meningioma.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 22, 2019

Volume

9

Issue

1

Start / End Page

309

Location

England

Related Subject Headings

  • Risk Factors
  • Odds Ratio
  • Obesity
  • Meningioma
  • Mendelian Randomization Analysis
  • Humans
  • Genome-Wide Association Study
  • Genetic Variation
  • Case-Control Studies
  • Body Mass Index
 

Citation

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Takahashi, H., Cornish, A. J., Sud, A., Law, P. J., Disney-Hogg, L., Calvocoressi, L., … Houlston, R. S. (2019). Mendelian randomization provides support for obesity as a risk factor for meningioma. Sci Rep, 9(1), 309. https://doi.org/10.1038/s41598-018-36186-6
Takahashi, Hannah, Alex J. Cornish, Amit Sud, Philip J. Law, Linden Disney-Hogg, Lisa Calvocoressi, Lingeng Lu, et al. “Mendelian randomization provides support for obesity as a risk factor for meningioma.Sci Rep 9, no. 1 (January 22, 2019): 309. https://doi.org/10.1038/s41598-018-36186-6.
Takahashi H, Cornish AJ, Sud A, Law PJ, Disney-Hogg L, Calvocoressi L, et al. Mendelian randomization provides support for obesity as a risk factor for meningioma. Sci Rep. 2019 Jan 22;9(1):309.
Takahashi, Hannah, et al. “Mendelian randomization provides support for obesity as a risk factor for meningioma.Sci Rep, vol. 9, no. 1, Jan. 2019, p. 309. Pubmed, doi:10.1038/s41598-018-36186-6.
Takahashi H, Cornish AJ, Sud A, Law PJ, Disney-Hogg L, Calvocoressi L, Lu L, Hansen HM, Smirnov I, Walsh KM, Schramm J, Hoffmann P, Nöthen MM, Jöckel K-H, Schildkraut JM, Simon M, Bondy M, Wrensch M, Wiemels JL, Claus EB, Turnbull C, Houlston RS. Mendelian randomization provides support for obesity as a risk factor for meningioma. Sci Rep. 2019 Jan 22;9(1):309.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 22, 2019

Volume

9

Issue

1

Start / End Page

309

Location

England

Related Subject Headings

  • Risk Factors
  • Odds Ratio
  • Obesity
  • Meningioma
  • Mendelian Randomization Analysis
  • Humans
  • Genome-Wide Association Study
  • Genetic Variation
  • Case-Control Studies
  • Body Mass Index