A systems-based model of Alzheimer's disease.
Journal Article (Journal Article)
The new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease has been developed to accelerate drug discovery and offer a common structure and language to construct new Alzheimer's disease conceptual models. However, as a "complex" disease, a model based on systems-level understanding is needed to accommodate the complex, interacting etiologic pathways and the system-level changes associated with Alzheimer's disease pathogenesis and interventions that are currently known and which will be identified in the future. To accomplish this, the evolution of the structure of the research framework itself should be encouraged.
Full Text
Duke Authors
Cited Authors
- Tang, Y; Lutz, MW; Xing, Y
Published Date
- January 2019
Published In
Volume / Issue
- 15 / 1
Start / End Page
- 168 - 171
PubMed ID
- 30102884
Electronic International Standard Serial Number (EISSN)
- 1552-5279
Digital Object Identifier (DOI)
- 10.1016/j.jalz.2018.06.3058
Language
- eng
Conference Location
- United States