Accuracy and generalization capability of an automatic method for the detection of typical brain hypometabolism in prodromal Alzheimer disease.

Journal Article (Journal Article)

PURPOSE: The aim of this study was to verify the reliability and generalizability of an automatic tool for the detection of Alzheimer-related hypometabolic pattern based on a Support-Vector-Machine (SVM) model analyzing 18F-fluorodeoxyglucose (FDG) PET data. METHODS: The SVM model processed metabolic data from anatomical volumes of interest also considering interhemispheric asymmetries. It was trained on a homogeneous dataset from a memory clinic center and tested on an independent multicentric dataset drawn from the Alzheimer's Disease Neuroimaging Initiative. Subjects were included in the study and classified based on a diagnosis confirmed after an adequate follow-up time. RESULTS: The accuracy of the discrimination between patients with Alzheimer Disease (AD), in either prodromal or dementia stage, and normal aging subjects was 95.8%, after cross-validation, in the training set. The accuracy of the same model in the testing set was 86.5%. The role of the two datasets was then reversed, and the accuracy was 89.8% in the multicentric training set and 88.0% in the monocentric testing set. The classification rate was also evaluated in different subgroups, including non-converter mild cognitive impairment (MCI) patients, subjects with MCI reverted to normal conditions and subjects with non-confirmed memory concern. The percent of pattern detections increased from 77% in early prodromal AD to 91% in AD dementia, while it was about 10% for healthy controls and non-AD patients. CONCLUSIONS: The present findings show a good level of reproducibility and generalizability of a model for detecting the hypometabolic pattern in AD and confirm the accuracy of FDG-PET in Alzheimer disease.

Full Text

Duke Authors

Cited Authors

  • De Carli, F; Nobili, F; Pagani, M; Bauckneht, M; Massa, F; Grazzini, M; Jonsson, C; Peira, E; Morbelli, S; Arnaldi, D; Alzheimer’s Disease Neuroimaging Initiative,

Published Date

  • February 2019

Published In

Volume / Issue

  • 46 / 2

Start / End Page

  • 334 - 347

PubMed ID

  • 30382303

Electronic International Standard Serial Number (EISSN)

  • 1619-7089

Digital Object Identifier (DOI)

  • 10.1007/s00259-018-4197-7


  • eng

Conference Location

  • Germany