Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research.

Journal Article (Journal Article;Review)

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and is transmitted in both health-care and community settings is also a leading cause of bacteraemia, endocarditis, skin and soft tissue infections, bone and joint infections and hospital-acquired infections. Genetically diverse, the epidemiology of MRSA is primarily characterized by the serial emergence of epidemic strains. Although its incidence has recently declined in some regions, MRSA still poses a formidable clinical threat, with persistently high morbidity and mortality. Successful treatment remains challenging and requires the evaluation of both novel antimicrobials and adjunctive aspects of care, such as infectious disease consultation, echocardiography and source control. In this Review, we provide an overview of basic and clinical MRSA research and summarize the expansive body of literature on the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA.

Full Text

Duke Authors

Cited Authors

  • Turner, NA; Sharma-Kuinkel, BK; Maskarinec, SA; Eichenberger, EM; Shah, PP; Carugati, M; Holland, TL; Fowler, VG

Published Date

  • April 2019

Published In

Volume / Issue

  • 17 / 4

Start / End Page

  • 203 - 218

PubMed ID

  • 30737488

Pubmed Central ID

  • PMC6939889

Electronic International Standard Serial Number (EISSN)

  • 1740-1534

Digital Object Identifier (DOI)

  • 10.1038/s41579-018-0147-4


  • eng

Conference Location

  • England