Endochondral ossification


Book Section

© 2019 American Society for Bone and Mineral Research. The endochondral ossification, the process responsible for generating most of the skeleton, requires a cartilage intermediate before forming bone. This chapter discusses the major cellular events of endochondral ossification: chondrogenesis, chondrocyte hypertrophy, and osteoblast differentiation, as well as important molecular mediators governing each of these processes. Calcification and ossification of the endochondral skeleton begins with chondrocyte hypertrophy. During this process, columnar chondrocytes located at the center of growing cartilage rudiments, also known as prehypertrophic and hypertrophic chondrocytes, undergo further differentiation after exiting the cell cycle. Osteoblasts are responsible for producing and secreting a combination of extracellular proteins that comprise the bone matrix. The chapter highlights critical murine studies using sophisticated genetic approaches to determine the functions for many of the transcriptional regulators and signaling molecules important in coordinating proper development of the endochondral skeleton.

Full Text

Duke Authors

Cited Authors

  • Karner, CM; Hilton, MJ

Published Date

  • January 1, 2018

Book Title

  • Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Start / End Page

  • 12 - 19

International Standard Book Number 13 (ISBN-13)

  • 9781119266563

Digital Object Identifier (DOI)

  • 10.1002/9781119266594.ch2

Citation Source

  • Scopus