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The role of thoracoscopic pneumonectomy in the management of non-small cell lung cancer: A multicenter study.

Publication ,  Journal Article
Yang, C-FJ; Yendamuri, S; Mayne, NR; Battoo, A; Wang, H; Meyerhoff, RR; Vandusen, K; Hirji, SA; Berry, MF; McKenna, RJ; Demmy, TL; D'Amico, TA
Published in: J Thorac Cardiovasc Surg
July 2019

OBJECTIVE: The objective of this study was to evaluate the impact of the video-assisted thoracoscopic (VATS) approach on the outcomes of patients who underwent pneumonectomy. METHODS: The effect of the surgical approach on perioperative complications and survival in patients who underwent pneumonectomy for nonmetastatic non-small cell lung cancer across 3 institutions (2000-2016) was assessed using multivariable logistic regression, Cox proportional hazards analysis, and propensity-score matching. Completion pneumonectomies were excluded from this study, and an "intent-to-treat" analysis was performed. RESULTS: During the study period, 359 patients met inclusion criteria and underwent pneumonectomy for nonmetastatic non-small cell lung cancer; 124 (35%) underwent pneumonectomy via VATS and 235 (65%) via thoracotomy. Perioperative mortality (VATS, 7% [n = 9] vs open, 8% [n = 19]; P = .75) and morbidity (VATS, 28% [n = 35] vs open, 28% [n = 65]; P = .91) were similar between the groups, even after multivariable adjustment. VATS showed similar 5-year survival when compared with thoracotomy in unadjusted analysis (47% [95% confidence interval (CI), 36-56] vs 33% [95% CI, 27-40]; P = .19), even after multivariable adjustment (hazard ratio, 0.76 [95% CI, 0.50-1.18]; P = .23). In a propensity score-matched analysis that balanced patient characteristics, there were no significant differences found in overall survival between the 2 groups (P = .69). CONCLUSIONS: Although the role of VATS pneumonectomy will likely become clearer as more surgeons report results, this multicenter study suggests that the VATS approach for pneumonectomy can be performed safely, with at least equivalent oncologic outcomes when compared with thoracotomy.

Duke Scholars

Published In

J Thorac Cardiovasc Surg

DOI

EISSN

1097-685X

Publication Date

July 2019

Volume

158

Issue

1

Start / End Page

252 / 264.e2

Location

United States

Related Subject Headings

  • Thoracotomy
  • Thoracic Surgery, Video-Assisted
  • Survival Analysis
  • Retrospective Studies
  • Respiratory System
  • Proportional Hazards Models
  • Propensity Score
  • Pneumonectomy
  • Middle Aged
  • Male
 

Citation

APA
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MLA
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Yang, C.-F., Yendamuri, S., Mayne, N. R., Battoo, A., Wang, H., Meyerhoff, R. R., … D’Amico, T. A. (2019). The role of thoracoscopic pneumonectomy in the management of non-small cell lung cancer: A multicenter study. J Thorac Cardiovasc Surg, 158(1), 252-264.e2. https://doi.org/10.1016/j.jtcvs.2018.12.001
Yang, Chi-Fu Jeffrey, Sai Yendamuri, Nicholas R. Mayne, Athar Battoo, Hanghang Wang, R Ryan Meyerhoff, Keith Vandusen, et al. “The role of thoracoscopic pneumonectomy in the management of non-small cell lung cancer: A multicenter study.J Thorac Cardiovasc Surg 158, no. 1 (July 2019): 252-264.e2. https://doi.org/10.1016/j.jtcvs.2018.12.001.
Yang C-FJ, Yendamuri S, Mayne NR, Battoo A, Wang H, Meyerhoff RR, et al. The role of thoracoscopic pneumonectomy in the management of non-small cell lung cancer: A multicenter study. J Thorac Cardiovasc Surg. 2019 Jul;158(1):252-264.e2.
Yang, Chi-Fu Jeffrey, et al. “The role of thoracoscopic pneumonectomy in the management of non-small cell lung cancer: A multicenter study.J Thorac Cardiovasc Surg, vol. 158, no. 1, July 2019, pp. 252-264.e2. Pubmed, doi:10.1016/j.jtcvs.2018.12.001.
Yang C-FJ, Yendamuri S, Mayne NR, Battoo A, Wang H, Meyerhoff RR, Vandusen K, Hirji SA, Berry MF, McKenna RJ, Demmy TL, D’Amico TA. The role of thoracoscopic pneumonectomy in the management of non-small cell lung cancer: A multicenter study. J Thorac Cardiovasc Surg. 2019 Jul;158(1):252-264.e2.
Journal cover image

Published In

J Thorac Cardiovasc Surg

DOI

EISSN

1097-685X

Publication Date

July 2019

Volume

158

Issue

1

Start / End Page

252 / 264.e2

Location

United States

Related Subject Headings

  • Thoracotomy
  • Thoracic Surgery, Video-Assisted
  • Survival Analysis
  • Retrospective Studies
  • Respiratory System
  • Proportional Hazards Models
  • Propensity Score
  • Pneumonectomy
  • Middle Aged
  • Male