Performance of the Accelerate Diagnostics PhenoTM system with resin-containing BacT/ALERT® Plus blood culture bottles.

Published

Journal Article

Bacteremia and septicemia require rapid identification (ID) and antimicrobial susceptibility testing (AST) to start targeted, appropriate therapy. To answer this need, Accelerate Diagnostics, Inc., developed the Accelerate Pheno™ system (AXDX), a fast ID and phenotypic AST platform. Performance of a pre-FDA clearance version of AXDX was evaluated using 261 positive BacT/ALERT® Plus bottles and compared with standard of care (SOC). Average time to ID was reduced by 24.9±6.9 h and AST by 36.7±18.9 h compared with SOC. AXDX reports ID and AST of blood pathogens in 1.9 and 7.1 h. Positive percent agreement and negative percent agreement of AXDX ID were 94.5% and 98.9%, respectively. AXDX AST had an essential agreement of 96.5% and categorical agreement of 94.6% with 4 major errors and 7 very major errors. AXDX performance was acceptable for all 3 bottle types. Rapid ID and AST with AXDX could impact patient care and antimicrobial stewardship.

Full Text

Cited Authors

  • Starr, KF; Robinson, DC; Hazen, KC

Published Date

  • June 2019

Published In

Volume / Issue

  • 94 / 2

Start / End Page

  • 122 - 128

PubMed ID

  • 30718159

Pubmed Central ID

  • 30718159

Electronic International Standard Serial Number (EISSN)

  • 1879-0070

Digital Object Identifier (DOI)

  • 10.1016/j.diagmicrobio.2019.01.002

Language

  • eng

Conference Location

  • United States