Implantation of cardiac resynchronization therapy devices represents one of the more challenging and time-consuming procedures for the clinical electrophysiologist. This article reviews several strategies used to improve efficiency, safety, and effectiveness of cardiac resynchronization therapy implantation. The cornerstone of our strategy to improve efficiency, safety, and quality of cardiac resynchronization therapy implantation is the use of a telescoping guide system with high-quality venography. Competency in subclavian venoplasty and snaring techniques are essential to maintain efficiency and effectiveness during difficult cases.