Role of imaging in low-grade cutaneous B-cell lymphoma presenting in the skin.

Journal Article (Journal Article)

BACKGROUND: Whole-body imaging is the current standard of care for staging all patients presenting with skin lesions of B-cell lymphomas (BCLs), regardless of skin disease extent; however, supporting data are lacking. OBJECTIVE: To determine the clinical utility of imaging in the detection of systemic involvement in low-grade cutaneous BCLs in the skin. METHODS: Retrospective cohort analysis of patients presenting with cutaneous lesions of BCLs at Memorial Sloan Kettering Cancer Center and Stanford University during 1997-2016. RESULTS: At initial staging, of the 522 patients, extracutaneous disease was noted in 3.6% and 8.8% of patients with marginal zone lymphoma (MZL, n = 306) and follicle center lymphoma (FCL, n = 216) histology, respectively. In patients with systemic involvement, imaging alone identified 81.8% (9/11) of MZL cases and 89.4% of follicular lymphoma cases. In primary cutaneous MZL, 1.7% of patients subsequently had extracutaneous involvement (median follow-up 45 months), and in primary cutaneous FCL. 3.0% subsequently had extracutaneous involvement (median follow-up 47 months). LIMITATIONS: This was a retrospective study. CONCLUSION: Imaging is effective at identifying patients with systemic involvement in indolent BCLs present in the skin; however, incidence is low. After negative initial staging, primary cutaneous MZL patients may be followed clinically without routine imaging.

Full Text

Duke Authors

Cited Authors

  • Kheterpal, MK; Dai, J; Geller, S; Pulitzer, M; Ni, A; Myskowski, PL; Moskowitz, A; Kim, J; Hong, EK; Fong, S; Hoppe, RT; Kim, YH; Horwitz, SM

Published Date

  • October 2019

Published In

Volume / Issue

  • 81 / 4

Start / End Page

  • 970 - 976

PubMed ID

  • 30703460

Pubmed Central ID

  • PMC6661219

Electronic International Standard Serial Number (EISSN)

  • 1097-6787

Digital Object Identifier (DOI)

  • 10.1016/j.jaad.2019.01.037


  • eng

Conference Location

  • United States