Salvage laryngectomy and laryngopharyngectomy: Multicenter review of outcomes associated with a reconstructive approach.

Journal Article (Journal Article;Multicenter Study)

BACKGROUND: Surgeons have developed various reconstructive techniques to minimize the rate of pharyngocutaneous fistula and optimize functional outcome after salvage laryngectomy or laryngopharyngectomy. METHODS: Multicenter retrospective review at 33 institutions of 486 patients with a history of squamous cell carcinoma (SCC) of the larynx or hypopharynx previously treated with primary chemoradiotherapy (CRT) who required salvage surgery. Outcomes evaluated were overall fistula rate, fistula requiring reoperation, and 12-month speech and swallowing function. RESULTS: Primary closure of the hypopharynx was associated with a statistically higher overall fistula rate and fistula requiring reoperation compared to reconstruction with vascularized tissue augmentation. Vascularized tissue augmentation with muscle led to worse 12-month "understandability of speech" and "nutritional mode" scores compared to vascularized tissue augmentation without muscle. CONCLUSION: Vascularized tissue augmentation reduces the overall fistula rate and fistula requiring reoperation but vascularized tissue augmentation with muscle may impair speech and swallowing outcomes.

Full Text

Duke Authors

Cited Authors

  • Microvascular Committee of the American Academy of Otolaryngology-Head & Neck Surgery*,

Published Date

  • January 2019

Published In

Volume / Issue

  • 41 / 1

Start / End Page

  • 16 - 29

PubMed ID

  • 30508265

Electronic International Standard Serial Number (EISSN)

  • 1097-0347

Digital Object Identifier (DOI)

  • 10.1002/hed.25192


  • eng

Conference Location

  • United States