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MRI Clinical Ratings and Cognitive Function in a Cross-Sectional Population Study of Dementia: The Cache County Memory Study.

Publication ,  Journal Article
Tsui-Caldwell, YHW; Farrer, TJ; McDonnell, Z; Christensen, Z; Finuf, C; Bigler, ED; Tschanz, JT; Norton, MC; Welsh-Bohmer, KA
Published in: J Prev Alzheimers Dis
2019

BACKGROUND: White matter integrity in aging populations is associated with increased risk of cognitive decline, dementia diagnosis, and mortality. Population-based data can elucidate this association. OBJECTIVES: To examine the association between white matter integrity, as measured by a clinical rating scale of hyperintensities, and mental status in older adults including advanced aging. DESIGN: Scheltens Ratings Scale was used to qualitatively assess white matter (WM) hyperintensities in participants of the Cache County Memory Study (CCMS), an epidemiological study of Alzheimer's disease in an exceptionally long-lived population. Further, the relation between Mini-Mental State Exam (MMSE) and WM hyperintensities were explored. METHOD: Participants consisted of 415 individuals with dementia and 22 healthy controls. RESULTS: CCMS participants, including healthy controls, had high levels of WM pathology as measured by Scheltens Ratings Scale score. While age did not significantly relate to WM pathology, higher Scheltens Ratings Scale scores were associated with lower MMSE findings (correlation between -0.14 and -0.22; p < .05). CONCLUSIONS: WM pathology was common in this county-wide population sample of those ranging in age from 65 to 106. Increased WM burden was found to be significantly associated with decreased overall MMSE performance.

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Published In

J Prev Alzheimers Dis

DOI

EISSN

2426-0266

Publication Date

2019

Volume

6

Issue

2

Start / End Page

100 / 107

Location

Switzerland

Related Subject Headings

  • White Matter
  • Utah
  • Mental Status and Dementia Tests
  • Male
  • Magnetic Resonance Imaging
  • Longitudinal Studies
  • Humans
  • Female
  • Dementia
  • Cross-Sectional Studies
 

Citation

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Tsui-Caldwell, Y. H. W., Farrer, T. J., McDonnell, Z., Christensen, Z., Finuf, C., Bigler, E. D., … Welsh-Bohmer, K. A. (2019). MRI Clinical Ratings and Cognitive Function in a Cross-Sectional Population Study of Dementia: The Cache County Memory Study. J Prev Alzheimers Dis, 6(2), 100–107. https://doi.org/10.14283/jpad.2019.1
Tsui-Caldwell, Y. H. W., T. J. Farrer, Z. McDonnell, Z. Christensen, C. Finuf, E. D. Bigler, J. T. Tschanz, M. C. Norton, and K. A. Welsh-Bohmer. “MRI Clinical Ratings and Cognitive Function in a Cross-Sectional Population Study of Dementia: The Cache County Memory Study.J Prev Alzheimers Dis 6, no. 2 (2019): 100–107. https://doi.org/10.14283/jpad.2019.1.
Tsui-Caldwell YHW, Farrer TJ, McDonnell Z, Christensen Z, Finuf C, Bigler ED, et al. MRI Clinical Ratings and Cognitive Function in a Cross-Sectional Population Study of Dementia: The Cache County Memory Study. J Prev Alzheimers Dis. 2019;6(2):100–7.
Tsui-Caldwell, Y. H. W., et al. “MRI Clinical Ratings and Cognitive Function in a Cross-Sectional Population Study of Dementia: The Cache County Memory Study.J Prev Alzheimers Dis, vol. 6, no. 2, 2019, pp. 100–07. Pubmed, doi:10.14283/jpad.2019.1.
Tsui-Caldwell YHW, Farrer TJ, McDonnell Z, Christensen Z, Finuf C, Bigler ED, Tschanz JT, Norton MC, Welsh-Bohmer KA. MRI Clinical Ratings and Cognitive Function in a Cross-Sectional Population Study of Dementia: The Cache County Memory Study. J Prev Alzheimers Dis. 2019;6(2):100–107.

Published In

J Prev Alzheimers Dis

DOI

EISSN

2426-0266

Publication Date

2019

Volume

6

Issue

2

Start / End Page

100 / 107

Location

Switzerland

Related Subject Headings

  • White Matter
  • Utah
  • Mental Status and Dementia Tests
  • Male
  • Magnetic Resonance Imaging
  • Longitudinal Studies
  • Humans
  • Female
  • Dementia
  • Cross-Sectional Studies