[Management of the acute respiratory distress syndrome].

Journal Article (Journal Article;Review)

OBJECTIVE: To review the current support and treatment strategies of the acute respiratory distress syndrome. DATA SOURCES: Original data from our research laboratory and from representative scientific articles on acute respiratory distress syndrome and acute lung Injury searched through Medline. SUMMARY OF THE FINDINGS: Despite advances in the understanding of the pathogenesis of acute respiratory distress syndrome, this syndrome still results in significant morbidity and mortality. Mechanical ventilation, the main therapeutic modality for acute respiratory distress syndrome, is no longer considered simply a support modality, but a therapy capable of influencing the course of the disease. New ventilation strategies, such as high-frequency oscillatory ventilation appear to be promising. This text reviews the current knowledge of acute respiratory distress syndrome management, including conventional and non-conventional ventilation, the use of surfactant, nitric oxide, modulators of inflammation, extracorporeal membrane oxygenation and prone position. CONCLUSIONS: The last decade was marked by significant advances, such as the concept of protective ventilation for acute respiratory distress syndrome. The benefit of alternative strategies, such as high-frequency oscillatory ventilation, the use of surfactant and immunomodulators continue to be the target of study.

Full Text

Duke Authors

Cited Authors

  • Rotta, AT; Kunrath, CLB; Wiryawan, B

Published Date

  • November 2003

Published In

Volume / Issue

  • 79 Suppl 2 /

Start / End Page

  • S149 - S160

PubMed ID

  • 14647711

International Standard Serial Number (ISSN)

  • 0021-7557

Digital Object Identifier (DOI)

  • 10.2223/jped.1091


  • por

Conference Location

  • Brazil