[The impact of mechanical ventilation strategies that minimize atelectrauma in an experimental model of acute lung injury].

Journal Article (Journal Article;English Abstract)

OBJECTIVE:To evaluate whether ventilation strategies that target alveolar stabilization and prevention of atelectrauma would be associated with more favorable physiologic outcomes in a combined model of acute lung injury. METHODS:Thirty-nine rabbits were instrumented and ventilated with FiO(2) of 1.0. Combined lung injury was induced by an infusion of lipopolysaccharide and tracheal saline lavage. Animals were randomized to receive conventional ventilation with tidal volume of 10 ml/kg, PEEP of 4 cm H(2)O; conventional ventilation with surfactant (Infasurf, 3 mg/kg IT); partial liquid ventilation (18 ml/kg of perflubron IT); or high-frequency oscillatory ventilation with mean airway pressure of 14 cm H(2)O and frequency of 4 Hz. Uninjured ventilated animals served as controls. Conventional ventilation with surfactant, partial liquid ventilation and control groups were ventilated with settings identical to the conventional ventilation group. Animals were studied for 4 hours, during which serial blood gas measurements were obtained. After sacrifice, lungs were harvested for injury grading by a microscopic lung injury score and measurement of 4-hydroxy-nonenal, a marker of lipid peroxidation. RESULTS:Conventional ventilation resulted in hypoxia and greater evidence of lung injury. Animals treated with partial liquid ventilation, high-frequency oscillatory ventilation or conventional ventilation with surfactant had adequate oxygenation, but conventional ventilation with surfactant resulted in higher lung injury scores and increased pulmonary oxidative damage. CONCLUSION:Strategies that minimize atelectrauma (partial liquid ventilation and high-frequency oscillatory ventilation) are associated with adequate oxygenation and attenuated lung injury. Surfactant improves oxygenation in comparison to conventional ventilation alone but resulted in increased injury, presumably because the inadequately low PEEP was insufficient to stabilize the alveoli during expiration.

Full Text

Duke Authors

Cited Authors

  • Viana, MEG; Sargentelli, GA; Arruda, ALM; Wiryawan, B; Rotta, AT

Published Date

  • May 2004

Published In

Volume / Issue

  • 80 / 3

Start / End Page

  • 189 - 196

PubMed ID

  • 15192761

Pubmed Central ID

  • 15192761

Electronic International Standard Serial Number (EISSN)

  • 1678-4782

International Standard Serial Number (ISSN)

  • 0021-7557

Digital Object Identifier (DOI)

  • 10.2223/jped.1182


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