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Epigenome-wide association study of metabolic syndrome in African-American adults.

Publication ,  Journal Article
Akinyemiju, T; Do, AN; Patki, A; Aslibekyan, S; Zhi, D; Hidalgo, B; Tiwari, HK; Absher, D; Geng, X; Arnett, DK; Irvin, MR
Published in: Clin Epigenetics
2018

BACKGROUND: The high prevalence of obesity among US adults has resulted in significant increases in associated metabolic disorders such as diabetes, dyslipidemia, and high blood pressure. Together, these disorders constitute metabolic syndrome, a clinically defined condition highly prevalent among African-Americans. Identifying epigenetic alterations associated with metabolic syndrome may provide additional information regarding etiology beyond current evidence from genome-wide association studies. METHODS: Data on metabolic syndrome and DNA methylation was assessed on 614 African-Americans from the Hypertension Genetic Epidemiology Network (HyperGEN) study. Metabolic syndrome was defined using the joint harmonized criteria, and DNA methylation was assessed using the Illumina HumanMethylation450K Bead Chip assay on DNA extracted from buffy coat. Linear mixed effects regression models were used to examine the association between CpG methylation at > 450,000 CpG sites and metabolic syndrome adjusted for study covariates. Replication using DNA from a separate sample of 69 African-Americans, as well as meta-analysis combining both cohorts, was conducted. RESULTS: Two differentially methylated CpG sites in the IGF2BP1 gene on chromosome 17 (cg06638433; p value = 3.10 × 10- 7) and the ABCG1 gene on chromosome 21 (cg06500161; p value = 2.60 × 10- 8) were identified. Results for the ABCG1 gene remained statistically significant in the replication dataset and meta-analysis. CONCLUSION: Metabolic syndrome was consistently associated with increased methylation in the ABCG1 gene in the discovery and replication datasets, a gene that encodes a protein in the ATP-binding cassette transporter family and is involved in intra- and extra-cellular signaling and lipid transport.

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Published In

Clin Epigenetics

DOI

EISSN

1868-7083

Publication Date

2018

Volume

10

Start / End Page

49

Location

Germany

Related Subject Headings

  • RNA-Binding Proteins
  • Middle Aged
  • Metabolic Syndrome
  • Male
  • Humans
  • Genome-Wide Association Study
  • Female
  • Epigenomics
  • Epigenesis, Genetic
  • DNA Methylation
 

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Akinyemiju, T., Do, A. N., Patki, A., Aslibekyan, S., Zhi, D., Hidalgo, B., … Irvin, M. R. (2018). Epigenome-wide association study of metabolic syndrome in African-American adults. Clin Epigenetics, 10, 49. https://doi.org/10.1186/s13148-018-0483-2
Akinyemiju, Tomi, Anh N. Do, Amit Patki, Stella Aslibekyan, Degui Zhi, Bertha Hidalgo, Hemant K. Tiwari, et al. “Epigenome-wide association study of metabolic syndrome in African-American adults.Clin Epigenetics 10 (2018): 49. https://doi.org/10.1186/s13148-018-0483-2.
Akinyemiju T, Do AN, Patki A, Aslibekyan S, Zhi D, Hidalgo B, et al. Epigenome-wide association study of metabolic syndrome in African-American adults. Clin Epigenetics. 2018;10:49.
Akinyemiju, Tomi, et al. “Epigenome-wide association study of metabolic syndrome in African-American adults.Clin Epigenetics, vol. 10, 2018, p. 49. Pubmed, doi:10.1186/s13148-018-0483-2.
Akinyemiju T, Do AN, Patki A, Aslibekyan S, Zhi D, Hidalgo B, Tiwari HK, Absher D, Geng X, Arnett DK, Irvin MR. Epigenome-wide association study of metabolic syndrome in African-American adults. Clin Epigenetics. 2018;10:49.
Journal cover image

Published In

Clin Epigenetics

DOI

EISSN

1868-7083

Publication Date

2018

Volume

10

Start / End Page

49

Location

Germany

Related Subject Headings

  • RNA-Binding Proteins
  • Middle Aged
  • Metabolic Syndrome
  • Male
  • Humans
  • Genome-Wide Association Study
  • Female
  • Epigenomics
  • Epigenesis, Genetic
  • DNA Methylation