Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016: A Systematic Analysis for the Global Burden of Disease Study.

Published

Journal Article

Importance: The increasing burden due to cancer and other noncommunicable diseases poses a threat to human development, which has resulted in global political commitments reflected in the Sustainable Development Goals as well as the World Health Organization (WHO) Global Action Plan on Non-Communicable Diseases. To determine if these commitments have resulted in improved cancer control, quantitative assessments of the cancer burden are required. Objective: To assess the burden for 29 cancer groups over time to provide a framework for policy discussion, resource allocation, and research focus. Evidence Review: Cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs) were evaluated for 195 countries and territories by age and sex using the Global Burden of Disease study estimation methods. Levels and trends were analyzed over time, as well as by the Sociodemographic Index (SDI). Changes in incident cases were categorized by changes due to epidemiological vs demographic transition. Findings: In 2016, there were 17.2 million cancer cases worldwide and 8.9 million deaths. Cancer cases increased by 28% between 2006 and 2016. The smallest increase was seen in high SDI countries. Globally, population aging contributed 17%; population growth, 12%; and changes in age-specific rates, -1% to this change. The most common incident cancer globally for men was prostate cancer (1.4 million cases). The leading cause of cancer deaths and DALYs was tracheal, bronchus, and lung cancer (1.2 million deaths and 25.4 million DALYs). For women, the most common incident cancer and the leading cause of cancer deaths and DALYs was breast cancer (1.7 million incident cases, 535 000 deaths, and 14.9 million DALYs). In 2016, cancer caused 213.2 million DALYs globally for both sexes combined. Between 2006 and 2016, the average annual age-standardized incidence rates for all cancers combined increased in 130 of 195 countries or territories, and the average annual age-standardized death rates decreased within that timeframe in 143 of 195 countries or territories. Conclusions and Relevance: Large disparities exist between countries in cancer incidence, deaths, and associated disability. Scaling up cancer prevention and ensuring universal access to cancer care are required for health equity and to fulfill the global commitments for noncommunicable disease and cancer control.

Full Text

Duke Authors

Cited Authors

  • Global Burden of Disease Cancer Collaboration, ; Fitzmaurice, C; Akinyemiju, TF; Al Lami, FH; Alam, T; Alizadeh-Navaei, R; Allen, C; Alsharif, U; Alvis-Guzman, N; Amini, E; Anderson, BO; Aremu, O; Artaman, A; Asgedom, SW; Assadi, R; Atey, TM; Avila-Burgos, L; Awasthi, A; Ba Saleem, HO; Barac, A; Bennett, JR; Bensenor, IM; Bhakta, N; Brenner, H; Cahuana-Hurtado, L; Castañeda-Orjuela, CA; Catalá-López, F; Choi, J-YJ; Christopher, DJ; Chung, S-C; Curado, MP; Dandona, L; Dandona, R; das Neves, J; Dey, S; Dharmaratne, SD; Doku, DT; Driscoll, TR; Dubey, M; Ebrahimi, H; Edessa, D; El-Khatib, Z; Endries, AY; Fischer, F; Force, LM; Foreman, KJ; Gebrehiwot, SW; Gopalani, SV; Grosso, G; Gupta, R; Gyawali, B; Hamadeh, RR; Hamidi, S; Harvey, J; Hassen, HY; Hay, RJ; Hay, SI; Heibati, B; Hiluf, MK; Horita, N; Hosgood, HD; Ilesanmi, OS; Innos, K; Islami, F; Jakovljevic, MB; Johnson, SC; Jonas, JB; Kasaeian, A; Kassa, TD; Khader, YS; Khan, EA; Khan, G; Khang, Y-H; Khosravi, MH; Khubchandani, J; Kopec, JA; Kumar, GA; Kutz, M; Lad, DP; Lafranconi, A; Lan, Q; Legesse, Y; Leigh, J; Linn, S; Lunevicius, R; Majeed, A; Malekzadeh, R; Malta, DC; Mantovani, LG; McMahon, BJ; Meier, T; Melaku, YA; Melku, M; Memiah, P; Mendoza, W; Meretoja, TJ; Mezgebe, HB; Miller, TR; Mohammed, S; Mokdad, AH; Moosazadeh, M; Moraga, P; Mousavi, SM; Nangia, V; Nguyen, CT; Nong, VM; Ogbo, FA; Olagunju, AT; Pa, M; Park, E-K; Patel, T; Pereira, DM; Pishgar, F; Postma, MJ; Pourmalek, F; Qorbani, M; Rafay, A; Rawaf, S; Rawaf, DL; Roshandel, G; Safiri, S; Salimzadeh, H; Sanabria, JR; Santric Milicevic, MM; Sartorius, B; Satpathy, M; Sepanlou, SG; Shackelford, KA; Shaikh, MA; Sharif-Alhoseini, M; She, J; Shin, M-J; Shiue, I; Shrime, MG; Sinke, AH; Sisay, M; Sligar, A; Sufiyan, MB; Sykes, BL; Tabarés-Seisdedos, R; Tessema, GA; Topor-Madry, R; Tran, TT; Tran, BX; Ukwaja, KN; Vlassov, VV; Vollset, SE; Weiderpass, E; Williams, HC; Yimer, NB; Yonemoto, N; Younis, MZ; Murray, CJL; Naghavi, M

Published Date

  • November 1, 2018

Published In

Volume / Issue

  • 4 / 11

Start / End Page

  • 1553 - 1568

PubMed ID

  • 29860482

Pubmed Central ID

  • 29860482

Electronic International Standard Serial Number (EISSN)

  • 2374-2445

Digital Object Identifier (DOI)

  • 10.1001/jamaoncol.2018.2706

Language

  • eng

Conference Location

  • United States