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Early life growth, socioeconomic status, and mammographic breast density in an urban US birth cohort.

Publication ,  Journal Article
Akinyemiju, TF; Tehranifar, P; Flom, JD; Liao, Y; Wei, Y; Terry, MB
Published in: Ann Epidemiol
August 2016

PURPOSE: Rapid infant and childhood growth has been associated with chronic disease later in life, including breast cancer. Early life socioeconomic status (SES) influences childhood growth, but few studies have prospective measures from birth to consider the effects of early life growth and SES on breast cancer risk. METHODS: We used prospectively measured early life SES and growth (percentile weight change in height and weight between each pair of consecutive time points at birth, 4 months, 1 and 7 years). We performed linear regression models to obtain standardized estimates of the association between 1 standard deviation increase in early life SES and growth and adult mammographic density (MD), a strong risk factor for breast cancer, in a diverse birth cohort (n = 151; 37% white, 38% black, 25% Puerto Rican; average age at mammogram = 42.4). RESULTS: In models adjusted for race/ethnicity, prenatal factors, birthweight, infant and childhood growth, and adult body mass index, percentile weight change from 1 year to 7 years was inversely associated with percent MD (standardized coefficient (Stdβ) = -0.28, 95% CI: -0.55 to -0.01), and higher early life SES was positively associated with percent MD (Stdβ = 0.24, 95% CI: 0.04-0.43). Similar associations were observed for dense area, but those estimates were not statistically significant. CONCLUSIONS: These results suggest opposite and independent effects of early life SES and growth on MD.

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Published In

Ann Epidemiol

DOI

EISSN

1873-2585

Publication Date

August 2016

Volume

26

Issue

8

Start / End Page

540 / 545.e2

Location

United States

Related Subject Headings

  • White People
  • Urban Population
  • United States
  • Socioeconomic Factors
  • Prospective Studies
  • Predictive Value of Tests
  • Multivariate Analysis
  • Mammography
  • Linear Models
  • Infant, Newborn
 

Citation

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Akinyemiju, T. F., Tehranifar, P., Flom, J. D., Liao, Y., Wei, Y., & Terry, M. B. (2016). Early life growth, socioeconomic status, and mammographic breast density in an urban US birth cohort. Ann Epidemiol, 26(8), 540-545.e2. https://doi.org/10.1016/j.annepidem.2016.06.011
Akinyemiju, Tomi F., Parisa Tehranifar, Julie D. Flom, Yuyan Liao, Ying Wei, and Mary Beth Terry. “Early life growth, socioeconomic status, and mammographic breast density in an urban US birth cohort.Ann Epidemiol 26, no. 8 (August 2016): 540-545.e2. https://doi.org/10.1016/j.annepidem.2016.06.011.
Akinyemiju TF, Tehranifar P, Flom JD, Liao Y, Wei Y, Terry MB. Early life growth, socioeconomic status, and mammographic breast density in an urban US birth cohort. Ann Epidemiol. 2016 Aug;26(8):540-545.e2.
Akinyemiju, Tomi F., et al. “Early life growth, socioeconomic status, and mammographic breast density in an urban US birth cohort.Ann Epidemiol, vol. 26, no. 8, Aug. 2016, pp. 540-545.e2. Pubmed, doi:10.1016/j.annepidem.2016.06.011.
Akinyemiju TF, Tehranifar P, Flom JD, Liao Y, Wei Y, Terry MB. Early life growth, socioeconomic status, and mammographic breast density in an urban US birth cohort. Ann Epidemiol. 2016 Aug;26(8):540-545.e2.
Journal cover image

Published In

Ann Epidemiol

DOI

EISSN

1873-2585

Publication Date

August 2016

Volume

26

Issue

8

Start / End Page

540 / 545.e2

Location

United States

Related Subject Headings

  • White People
  • Urban Population
  • United States
  • Socioeconomic Factors
  • Prospective Studies
  • Predictive Value of Tests
  • Multivariate Analysis
  • Mammography
  • Linear Models
  • Infant, Newborn