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Investigating hemodynamic response variability at the group level using basis functions.

Publication ,  Journal Article
Steffener, J; Tabert, M; Reuben, A; Stern, Y
Published in: NeuroImage
February 2010

Introduced is a general framework for performing group-level analyses of fMRI data using any basis set of two functions (i.e., the canonical hemodynamic response function and its first derivative) to model the hemodynamic response to neural activity. The approach allows for flexible implementation of physiologically based restrictions on the results. Information from both basis functions is used at the group level and the limitations avoid physiologically ambiguous or implausible results. This allows for investigation of specific BOLD activity such as hemodynamic responses peaking within a specified temporal range (i.e., 4-5 s). The general nature of the presented approach allows for applications using basis sets specifically designed to investigate various physiologic phenomena, i.e., age-related variability in poststimulus undershoot, hemodynamic responses measured with cerebral blood flow imaging, or subject-specific basis sets. An example using data from a group of healthy young participants demonstrates the methods and the specific steps to study poststimulus variability are discussed. The approach is completely implemented within the general linear model and requires minimal programmatic calculations.

Duke Scholars

Published In

NeuroImage

DOI

EISSN

1095-9572

ISSN

1053-8119

Publication Date

February 2010

Volume

49

Issue

3

Start / End Page

2113 / 2122

Related Subject Headings

  • Young Adult
  • Photic Stimulation
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Image Interpretation, Computer-Assisted
  • Humans
  • Hemodynamics
  • Female
  • Cerebrovascular Circulation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Steffener, J., Tabert, M., Reuben, A., & Stern, Y. (2010). Investigating hemodynamic response variability at the group level using basis functions. NeuroImage, 49(3), 2113–2122. https://doi.org/10.1016/j.neuroimage.2009.11.014
Steffener, Jason, Matthias Tabert, Aaron Reuben, and Yaakov Stern. “Investigating hemodynamic response variability at the group level using basis functions.NeuroImage 49, no. 3 (February 2010): 2113–22. https://doi.org/10.1016/j.neuroimage.2009.11.014.
Steffener J, Tabert M, Reuben A, Stern Y. Investigating hemodynamic response variability at the group level using basis functions. NeuroImage. 2010 Feb;49(3):2113–22.
Steffener, Jason, et al. “Investigating hemodynamic response variability at the group level using basis functions.NeuroImage, vol. 49, no. 3, Feb. 2010, pp. 2113–22. Epmc, doi:10.1016/j.neuroimage.2009.11.014.
Steffener J, Tabert M, Reuben A, Stern Y. Investigating hemodynamic response variability at the group level using basis functions. NeuroImage. 2010 Feb;49(3):2113–2122.
Journal cover image

Published In

NeuroImage

DOI

EISSN

1095-9572

ISSN

1053-8119

Publication Date

February 2010

Volume

49

Issue

3

Start / End Page

2113 / 2122

Related Subject Headings

  • Young Adult
  • Photic Stimulation
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Image Interpretation, Computer-Assisted
  • Humans
  • Hemodynamics
  • Female
  • Cerebrovascular Circulation