Targeting androgen receptor-independent pathways in therapy-resistant prostate cancer.

Journal Article (Journal Article;Review)

Since androgen receptor (AR) signaling is critically required for the development of prostate cancer (PCa), targeting AR axis has been the standard treatment of choice for advanced and metastatic PCa. Unfortunately, although the tumor initially responds to the therapy, treatment resistance eventually develops and the disease will progress. It is therefore imperative to identify the mechanisms of therapeutic resistance and novel molecular targets that are independent of AR signaling. Recent advances in pathology, molecular biology, genetics and genomics research have revealed novel AR-independent pathways that contribute to PCa carcinogenesis and progression. They include neuroendocrine differentiation, cell metabolism, DNA damage repair pathways and immune-mediated mechanisms. The development of novel agents targeting the non-AR mechanisms holds great promise to treat PCa that does not respond to AR-targeted therapies.

Full Text

Duke Authors

Cited Authors

  • Xu, L; Chen, J; Liu, W; Liang, C; Hu, H; Huang, J

Published Date

  • January 2019

Published In

Volume / Issue

  • 6 / 1

Start / End Page

  • 91 - 98

PubMed ID

  • 30775252

Pubmed Central ID

  • PMC6363598

International Standard Serial Number (ISSN)

  • 2214-3882

Digital Object Identifier (DOI)

  • 10.1016/j.ajur.2018.11.002


  • eng

Conference Location

  • Singapore