A mole rat's gut microbiota suggests selective influence of diet on microbial niche space and evolution.

Journal Article (Journal Article)

IMPACT STATEMENT: The composition of the microbiota is of critical importance for health and disease, and is receiving increased scientific and medical scrutiny. Of particular interest is the role of changing diets as a function of agriculture and, perhaps to an even greater extent, modern food processing. To probe the connection between diet and the gut's microbial community, the microbiota from a mole rat, a rodent with a relatively unusual diet, was analyzed in detail, and the microbes found were compared with previously identified organisms. The results show evidence of an adaptive radiation of some microbial clades, but relative stability in others. This suggests that the microbiota, like the genome, carries with it housekeeping components as well as other components which can evolve rapidly when the environment changes. This study provides a very broad view of the niche space in the gut and how factors such as diet might influence that niche space.

Full Text

Duke Authors

Cited Authors

  • Ren, L; Holzknecht, RA; Holzknecht, ZE; Kotzé, SH; Bowles, DE; Lin, SS; McKenney, EA; Parker, W

Published Date

  • April 2019

Published In

Volume / Issue

  • 244 / 6

Start / End Page

  • 471 - 483

PubMed ID

  • 30760029

Pubmed Central ID

  • PMC6547004

Electronic International Standard Serial Number (EISSN)

  • 1535-3699

Digital Object Identifier (DOI)

  • 10.1177/1535370219828703

Language

  • eng

Conference Location

  • England