Childhood Cancer Symptom Cluster: Leukemia and Health-Related Quality of Life.
Journal Article (Journal Article)
Objectives
To examine the relationship of the Childhood Cancer Symptom Cluster-Leukemia (CCSC-L) with health-related quality of life (HRQOL).Sample & setting
327 children receiving treatment for acute lymphoblastic leukemia from four pediatric oncology programs across the United States.Methods & variables
Participants completed fatigue, sleep disturbance, pain, nausea, and depression symptom questionnaires at four time points; these symptoms comprised the CCSC-L. HRQOL was measured at the start of postinduction therapy and then at the start of maintenance therapy. Relationships between the CCSC-L and HRQOL scores were examined with longitudinal parallel-process modeling.Results
The mean HRQOL significantly increased over time (p < 0.001). The CCSC-L had a significant negative association with HRQOL scores at the start of postinduction therapy (beta = -0.53, p < 0.005) and the start of maintenance therapy (beta = -0.33, p < 0.015). Participants with more severe symptoms in the CCSC-L over time had significantly lower HRQOL at the start of maintenance therapy (beta = -0.42, p < 0.005).Implications for nursing
Nurses are pivotal in providing management strategies to minimize symptom severity that may improve HRQOL.Full Text
Duke Authors
Cited Authors
- Rodgers, CC; Hooke, MC; Taylor, OA; Koerner, KM; Mitby, PA; Moore, IM; Scheurer, ME; Hockenberry, MJ; Pan, W
Published Date
- March 2019
Published In
Volume / Issue
- 46 / 2
Start / End Page
- 228 - 237
PubMed ID
- 30767969
Pubmed Central ID
- PMC8106538
Electronic International Standard Serial Number (EISSN)
- 1538-0688
International Standard Serial Number (ISSN)
- 0190-535X
Digital Object Identifier (DOI)
- 10.1188/19.onf.228-237
Language
- eng