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Molecular Classification and Emerging Targeted Therapy in Endometrial Cancer.

Publication ,  Journal Article
Yen, T-T; Wang, T-L; Fader, AN; Shih, I-M; Gaillard, S
Published in: Int J Gynecol Pathol
January 2020

Recent advances in molecular studies, especially genome-wide analyses, have revealed the landscape of genomic alterations present in endometrial carcinomas, and have provided valuable insight into the pathogenesis of this disease. The current challenges are in developing a molecular-morphologic classification system to enhance traditional pathologic diagnosis and in determining the optimal approach to using this new information to guide clinical management. Molecular assays may be particularly beneficial in allowing the earlier detection of endometrial cancer or precursor lesions and in guiding personalized treatment approaches. In this review, we describe the current molecular landscape of endometrial cancers, efforts underway to incorporate molecular alterations into the current classification systems, and the development of diagnostic tools for the early detection of endometrial cancer. Finally, we present opportunities for using these data to tailor therapeutic strategies. A comprehensive understanding of the molecular alterations responsible for the origination, relapse, and resistance patterns of this disease will ultimately improve outcomes for patients with endometrial cancer.

Duke Scholars

Published In

Int J Gynecol Pathol

DOI

EISSN

1538-7151

Publication Date

January 2020

Volume

39

Issue

1

Start / End Page

26 / 35

Location

United States

Related Subject Headings

  • Pathology
  • Mutation
  • Molecular Targeted Therapy
  • Humans
  • Genes, Neoplasm
  • Female
  • Endometrial Neoplasms
  • Early Detection of Cancer
  • 3215 Reproductive medicine
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yen, T.-T., Wang, T.-L., Fader, A. N., Shih, I.-M., & Gaillard, S. (2020). Molecular Classification and Emerging Targeted Therapy in Endometrial Cancer. Int J Gynecol Pathol, 39(1), 26–35. https://doi.org/10.1097/PGP.0000000000000585
Yen, Ting-Tai, Tian-Li Wang, Amanda N. Fader, Ie-Ming Shih, and Stéphanie Gaillard. “Molecular Classification and Emerging Targeted Therapy in Endometrial Cancer.Int J Gynecol Pathol 39, no. 1 (January 2020): 26–35. https://doi.org/10.1097/PGP.0000000000000585.
Yen T-T, Wang T-L, Fader AN, Shih I-M, Gaillard S. Molecular Classification and Emerging Targeted Therapy in Endometrial Cancer. Int J Gynecol Pathol. 2020 Jan;39(1):26–35.
Yen, Ting-Tai, et al. “Molecular Classification and Emerging Targeted Therapy in Endometrial Cancer.Int J Gynecol Pathol, vol. 39, no. 1, Jan. 2020, pp. 26–35. Pubmed, doi:10.1097/PGP.0000000000000585.
Yen T-T, Wang T-L, Fader AN, Shih I-M, Gaillard S. Molecular Classification and Emerging Targeted Therapy in Endometrial Cancer. Int J Gynecol Pathol. 2020 Jan;39(1):26–35.

Published In

Int J Gynecol Pathol

DOI

EISSN

1538-7151

Publication Date

January 2020

Volume

39

Issue

1

Start / End Page

26 / 35

Location

United States

Related Subject Headings

  • Pathology
  • Mutation
  • Molecular Targeted Therapy
  • Humans
  • Genes, Neoplasm
  • Female
  • Endometrial Neoplasms
  • Early Detection of Cancer
  • 3215 Reproductive medicine
  • 1114 Paediatrics and Reproductive Medicine