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Response to antiseizure medications in neonates with acute symptomatic seizures.

Publication ,  Journal Article
Glass, HC; Soul, JS; Chu, CJ; Massey, SL; Wusthoff, CJ; Chang, T; Cilio, MR; Bonifacio, SL; Abend, NS; Thomas, C; Lemmon, M; McCulloch, CE ...
Published in: Epilepsia
March 2019

In a prospective cohort of 534 neonates with acute symptomatic seizures, 66% had incomplete response to the initial loading dose of antiseizure medication (ASM). Treatment response did not differ by gestational age, sex, medication, or dose. The risk of incomplete response was highest for seizures due to intracranial hemorrhage and lowest for hypoxic-ischemic encephalopathy, although the difference was not significant after adjusting for high seizure burden and therapeutic hypothermia treatment. Future trial design may test ASMs in neonates with all acute symptomatic seizure etiologies and could target neonates with seizures refractory to an initial ASM.

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Published In

Epilepsia

DOI

EISSN

1528-1167

Publication Date

March 2019

Volume

60

Issue

3

Start / End Page

e20 / e24

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Seizures
  • Prospective Studies
  • Neurology & Neurosurgery
  • Male
  • Infant, Newborn, Diseases
  • Infant, Newborn
  • Humans
  • Female
  • Electroencephalography
 

Citation

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Glass, H. C., Soul, J. S., Chu, C. J., Massey, S. L., Wusthoff, C. J., Chang, T., … Neonatal Seizure Registry study group, . (2019). Response to antiseizure medications in neonates with acute symptomatic seizures. Epilepsia, 60(3), e20–e24. https://doi.org/10.1111/epi.14671
Glass, Hannah C., Janet S. Soul, Catherine J. Chu, Shavonne L. Massey, Courtney J. Wusthoff, Taeun Chang, Maria Roberta Cilio, et al. “Response to antiseizure medications in neonates with acute symptomatic seizures.Epilepsia 60, no. 3 (March 2019): e20–24. https://doi.org/10.1111/epi.14671.
Glass HC, Soul JS, Chu CJ, Massey SL, Wusthoff CJ, Chang T, et al. Response to antiseizure medications in neonates with acute symptomatic seizures. Epilepsia. 2019 Mar;60(3):e20–4.
Glass, Hannah C., et al. “Response to antiseizure medications in neonates with acute symptomatic seizures.Epilepsia, vol. 60, no. 3, Mar. 2019, pp. e20–24. Pubmed, doi:10.1111/epi.14671.
Glass HC, Soul JS, Chu CJ, Massey SL, Wusthoff CJ, Chang T, Cilio MR, Bonifacio SL, Abend NS, Thomas C, Lemmon M, McCulloch CE, Shellhaas RA, Neonatal Seizure Registry study group. Response to antiseizure medications in neonates with acute symptomatic seizures. Epilepsia. 2019 Mar;60(3):e20–e24.
Journal cover image

Published In

Epilepsia

DOI

EISSN

1528-1167

Publication Date

March 2019

Volume

60

Issue

3

Start / End Page

e20 / e24

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Seizures
  • Prospective Studies
  • Neurology & Neurosurgery
  • Male
  • Infant, Newborn, Diseases
  • Infant, Newborn
  • Humans
  • Female
  • Electroencephalography