Response to antiseizure medications in neonates with acute symptomatic seizures.

Journal Article (Journal Article)

In a prospective cohort of 534 neonates with acute symptomatic seizures, 66% had incomplete response to the initial loading dose of antiseizure medication (ASM). Treatment response did not differ by gestational age, sex, medication, or dose. The risk of incomplete response was highest for seizures due to intracranial hemorrhage and lowest for hypoxic-ischemic encephalopathy, although the difference was not significant after adjusting for high seizure burden and therapeutic hypothermia treatment. Future trial design may test ASMs in neonates with all acute symptomatic seizure etiologies and could target neonates with seizures refractory to an initial ASM.

Full Text

Duke Authors

Cited Authors

  • Glass, HC; Soul, JS; Chu, CJ; Massey, SL; Wusthoff, CJ; Chang, T; Cilio, MR; Bonifacio, SL; Abend, NS; Thomas, C; Lemmon, M; McCulloch, CE; Shellhaas, RA; Neonatal Seizure Registry study group,

Published Date

  • March 2019

Published In

Volume / Issue

  • 60 / 3

Start / End Page

  • e20 - e24

PubMed ID

  • 30790268

Pubmed Central ID

  • PMC6443409

Electronic International Standard Serial Number (EISSN)

  • 1528-1167

Digital Object Identifier (DOI)

  • 10.1111/epi.14671


  • eng

Conference Location

  • United States