2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections.

Journal Article (Journal Article)

Biofilm-associated implant-related bone and joint infections are clinically important due to the extensive morbidity, cost of care and socioeconomic burden that they cause. Research in the field of biofilms has expanded in the past two decades, however, there is still an immense knowledge gap related to many clinical challenges of these biofilm-associated infections. This subject was assigned to the Biofilm Workgroup during the second International Consensus Meeting on Musculoskeletal Infection held in Philadelphia USA (ICM 2018) (https://icmphilly.com). The main objective of the Biofilm Workgroup was to prepare a consensus document based on a review of the literature, prepared responses, discussion, and vote on thirteen biofilm related questions. The Workgroup commenced discussing and refining responses prepared before the meeting on day one using Delphi methodology, followed by a tally of responses using an anonymized voting system on the second day of ICM 2018. The Working group derived consensus on information about biofilms deemed relevant to clinical practice, pertaining to: (1) surface modifications to prevent/inhibit biofilm formation; (2) therapies to prevent and treat biofilm infections; (3) polymicrobial biofilms; (4) diagnostics to detect active and dormant biofilm in patients; (5) methods to establish minimal biofilm eradication concentration for biofilm bacteria; and (6) novel anti-infectives that are effective against biofilm bacteria. It was also noted that biomedical research funding agencies and the pharmaceutical industry should recognize these areas as priorities. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

Full Text

Duke Authors

Cited Authors

  • Saeed, K; McLaren, AC; Schwarz, EM; Antoci, V; Arnold, WV; Chen, AF; Clauss, M; Esteban, J; Gant, V; Hendershot, E; Hickok, N; Higuera, CA; Coraça-Huber, DC; Choe, H; Jennings, JA; Joshi, M; Li, WT; Noble, PC; Phillips, KS; Pottinger, PS; Restrepo, C; Rohde, H; Schaer, TP; Shen, H; Smeltzer, M; Stoodley, P; Webb, JCJ; Witsø, E

Published Date

  • May 2019

Published In

Volume / Issue

  • 37 / 5

Start / End Page

  • 1007 - 1017

PubMed ID

  • 30667567

Electronic International Standard Serial Number (EISSN)

  • 1554-527X

Digital Object Identifier (DOI)

  • 10.1002/jor.24229


  • eng

Conference Location

  • United States