Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration.

Journal Article (Journal Article;Review)

Skeletal muscle has remarkable regenerative capacity, relying on precise coordination between resident muscle stem cells (satellite cells) and the immune system. The age-related decline in skeletal muscle regenerative capacity contributes to the onset of sarcopenia, prolonged hospitalization, and loss of autonomy. Although several age-sensitive pathways have been identified, further investigation is needed to define targets of cellular dysfunction. Autophagy, a process of cellular catabolism, is emerging as a key regulator of muscle regeneration affecting stem cell, immune cell, and myofiber function. Muscle stem cell senescence is associated with a suppression of autophagy during key phases of the regenerative program. Macrophages, a key immune cell involved in muscle repair, also rely on autophagy to aid in tissue repair. This review will focus on the role of autophagy in various aspects of the regenerative program, including adult skeletal muscle stem cells, monocytes/macrophages, and corresponding age-associated dysfunction. Furthermore, we will highlight rejuvenation strategies that alter autophagy to improve muscle regenerative function.

Full Text

Duke Authors

Cited Authors

  • Lee, DE; Bareja, A; Bartlett, DB; White, JP

Published Date

  • February 20, 2019

Published In

Volume / Issue

  • 8 / 2

PubMed ID

  • 30791569

Pubmed Central ID

  • PMC6406986

International Standard Serial Number (ISSN)

  • 2073-4409

Digital Object Identifier (DOI)

  • 10.3390/cells8020183

Language

  • eng

Conference Location

  • Switzerland