High expression of long non-coding RNA H19 is required for efficient tumorigenesis induced by Bcr-Abl oncogene.


Journal Article

Dysregulation of non-coding RNA H19 has been observed in various tumors. However, it remains unknown whether H19 is involved in Bcr-Abl-induced leukemia. Here, we demonstrate a critical requirement for H19 in Bcr-Abl-mediated tumorigenesis. H19 was highly expressed in Bcr-Abl-transformed cell lines and primary cells derived from patients in a Bcr-Abl kinase-dependent manner. Silencing H19 expression sensitized leukemic cells to undergo imatinib-induced apoptosis and inhibited Bcr-Abl-induced tumor growth. Furthermore, H19 was shown to be regulated by c-Myc in Bcr-Abl-expressing cells. These results reveal an important role H19 plays in Bcr-Abl-mediated transformation and provide novel insights into complex mechanisms underlying Bcr-Abl-induced cancers.

Full Text

Cited Authors

  • Guo, G; Kang, Q; Chen, Q; Chen, Z; Wang, J; Tan, L; Chen, J-L

Published Date

  • May 2014

Published In

Volume / Issue

  • 588 / 9

Start / End Page

  • 1780 - 1786

PubMed ID

  • 24685695

Pubmed Central ID

  • 24685695

Electronic International Standard Serial Number (EISSN)

  • 1873-3468

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/j.febslet.2014.03.038


  • eng